Results 71 to 80 of about 165,959,854 (300)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Poincarè or the deep Need of Convention [PDF]

open access: yesIdeas y Valores, 2005
In the frame of the celebration of the century of the publication that gave way to the special theory of relativity, a semblance of the discussions generated from the philosophical implications that derive from the possibility of accepting non-euclidian ...
Carlos Alberto Cardona Suárez
doaj  

Artificial molecular machines and motors—Design and control of nanoscale motion

open access: yesFEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Different geometries for special relativity [PDF]

open access: yes, 2004
This paper introduces a different time-measuring convention for special relativity (SR), where a time interval t can be measured by dc, the distance traveled from an origin by the spherical wave-front of a light pulse c. Adoption of this convention leads
Crabbe, A
core  

About the origins of the general theory of relativity: Einstein's search for the truth [PDF]

open access: yes, 2005
On the 20th June 1933 Professor Einstein addressed a large and enthusiastic audience in the Victorian Gothic Bute Hall of the University of Glasgow. Einstein spoke 'About the Origins of the General Theory of Relativity'.
Trainer, M.
core   +2 more sources

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

open access: yesFEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Time in the theory of relativity: on natural clocks, proper time, the clock hypothesis, and all that [PDF]

open access: yes, 2013
When addressing the notion of proper time in the theory of relativity, it is usually taken for granted that the time read by an accelerated clock is given by the Minkowski proper time.
Bacelar Valente, Mario
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

What can we Learn about the Ontology of Space and Time from the Theory of Relativity [PDF]

open access: yes, 2012
This chapter presents an opinionated assessment of what we can learn about the ontology of space and time from the special and general theories of relativity.
Norton, John D.
core  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

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