Results 91 to 100 of about 167,610,246 (239)
David Hume and the Principle of Sufficient Reason
, 2006 This dissertation is meant as an investigation into the ground of the principle of sufficient reason. To me, there is almost no meatier a philosophical topic than the principle of sufficient reason and the prospect of the unconditioned.
Lee, Ginger
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A Few Words about Spinoza, a Philosopher of Few or, Perhaps, No Words
Journal of Spinoza Studies, 2022 Michael Della Rocca
doaj +1 more source
Clinical Impact of NOTCH3 Variant Location After First Stroke in CADASIL
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Despite its monogenic origin, Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy exhibits marked variability in clinical expression and severity. Variants in the NOTCH3 gene, within epidermal growth factor‐like repeat domains 1–6 or 7–34, are known to influence disease onset, but their impact ...
Léa Aguilhon +5 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw +5 more
wiley +1 more source
Locke's conception of property and the principle of sufficient reason
LOCKE'S CONCEPTION OF PROPERTY AND THE PRINCIPLE OF SUFFICIENT REASON Locke's conception of property and the principle of sufficient reason ...
Rapaczynski, Andrzej
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White Matter Microstructural Abnormalities in Neonatal Onset Genetic Epilepsy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Recent evidence indicates that epilepsy is associated with abnormal white matter. If seizures alter white matter, then the impact upon network function, epileptogenesis, and cognition could be pronounced in neonates undergoing rapid developmental myelination. Neonates with epilepsy due to nonstructural genetic causes provide a unique
Amanda G. Sandoval Karamian +8 more
wiley +1 more source
Leibniz on the PSR as a Regulative Principle of Rational Inquiry
Journal of Modern PhilosophyOne of Leibniz’s fundamental philosophical commitments is the principle of sufficient reason (PSR). Yet Leibniz’s precise understanding of this principle is elusive.
Juan Garcia Torres
doaj +2 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Gliomas have undergone a profound redefinition over the past decade, transitioning from morphology‐based entities to biologically coherent diseases defined by molecular alterations. The 2021 WHO Classification of Tumors of the Central Nervous System and its 2022 update formalize this shift, establishing integrated diagnosis as the global ...
Maria Guarnaccia, Sebastiano Cavallaro
wiley +1 more source
Reserves, Injury Severity, and Outcomes in Traumatic Brain Injury: A CENTER‐TBI Observational Study
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Reserve refers to the brain's ability to maintain function after an injury and strongly relates to traumatic brain injury (TBI) outcomes. This study examined (1) whether associations between pre‐injury reserve proxies and outcomes differed across injury severity categories, and (2) whether the impact of injury severity varied across ...
Natascha Ekdahl +6 more
wiley +1 more source
Deleuze's problematic principle of sufficient reason: From Hume to Bergson
The significance of the principle of sufficient reason for the philosophy of Deleuze has long been recognized. Predominantly drawing from Deleuze's two 1968 publications, Difference and Repetition and
Craig Lundy, Robin Durie
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