Results 101 to 110 of about 3,197,496 (264)

Intensity Trajectories During High-Intensity Interval Training and Their Impact on Health Outcomes in Adolescents: Evidence from School-Based PE Settings (Peer-Heart Studies)

Life
Background: High-intensity interval training (HIIT) is increasingly implemented in school-based physical education, yet little is known about how exercise intensity changes across repeated sessions and whether such trajectories are associated with ...
Jarosław Domaradzki, Dawid Koźlenia
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Principles of Equine Dentistry

Identifies, applies and and evaluates the principles of equine dentistry in relation to the horse, with coverage ranging from anatomy, biomechanics and examination to radiology, anaesthesia, trauma, disease and restoration. Top quality colour photographs
Wiggs, Robert B., Cox, Victor S., Quandt, Jane., O Klugh, David., Brannan, Randi D., Lowder, Michael Q., Tremaine, Henry., Emily, Peter.   +7 more
core  

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

physicochemical principles of pharmacy

, 2006
xiv,ill,492hal ...
Florence,Alexander, david,Attwood
core  

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Probabilitics Syimmetries and Invariance Principles

, 2005
xi.;ill.;510 hal.; 30 ...
Kallenberg. Olav
core  

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Dietary supplement use and knowledge among athletes: prevalence, compliance with AIS classification, and awareness of certification programs

Journal of the International Society of Sports Nutrition
Background The use of dietary supplements is widespread among athletes, with intake influenced by factors such as sport-discipline, competitive level, and gender.
Anna Broniecka, Aleksandra Sarachman, Aleksandra Zagrodna, Anna Książek   +3 more
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source