Results 81 to 90 of about 2,491,555 (315)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
, 2004 The concepts of quality and good management principles have beenaround for some time, but each has been treated separately and the twohave sometimes been considered unrelated topics.
Ross, Joel E., Omachonu, Vincent K.
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
, 2015 Sustainable Built Environments Senior CapstoneThe traditional architecture is replaced with modern architecture which delivers less sustainable designs. The houses consume more energy, are less useful, and eventually cost more money. The focus of social,
Landgren, William
core
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Frequency of Smoking and Specialized Awareness among Doctors and Nurses of Hospitals in Kerman, Iran [PDF]
Addiction and Health, 2013 Background: Nicotine is one of the strongest poisons. Every year about 75 thousand of Iranians die due to smoking. Since doctors and nurses have a major role in controlling smoking, this study tried to investigate the prevalence of cigarette smoking ...
Hakimeh Hoseainrezaee +3 more
doaj
Journal of Magnetic Resonance, 2011 The circumstances surrounding the realisation that NMR signal reception could be quantified in a simple fundamental manner using Lorentz's Principle of Reciprocity are described. The poor signal-to-noise ratio of the first European superconducting magnet is identified as a major motivating factor, together with the author's need to understand phenomena
openaire +3 more sources
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
SCRIPTed: A Journal of Law, Technology & Society, 2009 Asia Pacific Economic Cooperation (APEC) is a grouping of twenty-one member economies in the Asia Pacific Region. It was established in 1989 to facilitate economic growth, cooperation, trade and investment in the region.
Nigel Waters
doaj +1 more source