Results 71 to 80 of about 3,197,496 (264)
Frontiers in MedicineBackgroundAlcohol withdrawal syndrome (AWS) constitutes a critical clinical outcome across the spectrum of alcohol use disorders (AUD), comprising severe neuropsychological manifestations during early abstinence among individuals with alcohol dependence.
Adiveppal Nandini +5 more
doaj +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
, 2004 The concepts of quality and good management principles have beenaround for some time, but each has been treated separately and the twohave sometimes been considered unrelated topics.
Ross, Joel E., Omachonu, Vincent K.
core
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
, 2015 Sustainable Built Environments Senior CapstoneThe traditional architecture is replaced with modern architecture which delivers less sustainable designs. The houses consume more energy, are less useful, and eventually cost more money. The focus of social,
Landgren, William
core
Taʻzīrāt and Banā’ al-‘Uqalā’ in Penal Jurisprudence and Criminal Law [PDF]
مطالعات فقه اسلامی و مبانی حقوقThe element of banāʾ al-ʿuqalāʾ (the established practice of rational people) in jurisprudence and penal law is a source that has consistently drawn the attention of scholars and is considered a cornerstone of reasoning in penal matters.
Sayyid Hamidollah Hosseini +2 more
doaj +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source