Results 21 to 30 of about 97,942 (322)
A blood miRNA signature associates with sporadic Creutzfeldt-Jakob disease diagnosis
Nature Communications, 2020 Sporadic Creutzfeldt-Jakob disease (sCJD) is a rapidly progressive dementia. No clinical blood tests are available for diagnosis. The authors identified three miRNAs in whole-blood that are downregulated in sCJD patients, and discriminate sCJD from ...
Penny J. Norsworthy +10 more
doaj +1 more source
Structural insights into how augmin augments the mitotic spindle
Nature Communications, 2023 Cell division critically requires amplification of microtubules (MTs) in the bipolar mitotic spindle. This relies on the filamentous augmin complex that enables MT branching. Studies by Gabel et al., Zupa et al. and Travis et al.
Szymon W. Manka
doaj +1 more source
Hepatology, EarlyView., 2022 Hepatic endothelial Alk1 signaling protects from development of vascular malformations while maintaining organ‐specific endothelial differentiation and angiocrine portmanteau of the names Wingless and Int‐1 signaling. Abstract Background and Aims In hereditary hemorrhagic telangiectasia (HHT), severe liver vascular malformations are associated with ...
Christian David Schmid +20 more
wiley +1 more source
Genetic Risk Factors of Creutzfeldt-Jakob Disease in the Population of Newborns in Slovakia
Pathogens, 2021 The most frequent human prion disease is Creutzfeldt–Jakob disease (CJD). It occurs as sporadic (sCJD), genetic (gCJD), iatrogenic (iCJD) form and as variant CJD.
Dana Kosorinova +4 more
doaj +1 more source
Cryo-EM structure of a human prion fibril with a hydrophobic, protease-resistant core
Nature Structural & Molecular Biology, 2020 Self-templating assemblies of the human prion protein are clinically associated with transmissible spongiform encephalopathies. Here we present the cryo-EM structure of a denaturant- and protease-resistant fibril formed in vitro spontaneously by a 9.7 ...
C. Glynn +9 more
semanticscholar +1 more source
Adipose-derived mesenchymal stromal cells decrease prion-induced glial inflammation in vitro
Scientific Reports, 2022 Prion diseases are characterized by the cellular prion protein, PrPC, misfolding and aggregating into the infectious prion protein, PrPSc, which leads to neurodegeneration and death.
Arielle J. D. Hay +4 more
doaj +1 more source
RNA-binding proteins with prion-like domains in health and disease.
Biochemical Journal, 2017 Approximately 70 human RNA-binding proteins (RBPs) contain a prion-like domain (PrLD). PrLDs are low-complexity domains that possess a similar amino acid composition to prion domains in yeast, which enable several proteins, including Sup35 and Rnq1, to ...
A. F. Harrison, J. Shorter
semanticscholar +1 more source
A New Cell Model for Investigating Prion Strain Selection and Adaptation
Viruses, 2019 Prion diseases are fatal neurodegenerative diseases that affect humans and animals. Prion strains, conformational variants of misfolded prion proteins, are associated with distinct clinical and pathological phenotypes.
Alexandra Philiastides +5 more
doaj +1 more source
Genetic risk factors for Creutzfeldt-Jakob disease
Neurobiology of Disease, 2020 Prion diseases are a group of fatal neurodegenerative disorders of mammals that share a central role for prion protein (PrP, gene PRNP) in their pathogenesis.
Emma Jones, Simon Mead
doaj +1 more source
A multiplexed, paired-pooled droplet digital PCR assay for detection of SARS-CoV-2 in saliva
Scientific Reports, 2023 In response to the SARS-CoV-2 pandemic, we developed a multiplexed, paired-pool droplet digital PCR (MP4) screening assay. Key features of our assay are the use of minimally processed saliva, 8-sample paired pools, and reverse-transcription droplet ...
Kaitlyn Wagner +26 more
doaj +1 more source