Results 21 to 30 of about 67,311 (287)
Genetic Risk Factors of Creutzfeldt-Jakob Disease in the Population of Newborns in Slovakia
Pathogens, 2021 The most frequent human prion disease is Creutzfeldt–Jakob disease (CJD). It occurs as sporadic (sCJD), genetic (gCJD), iatrogenic (iCJD) form and as variant CJD.
Dana Kosorinova +4 more
doaj +1 more source
Adipose-derived mesenchymal stromal cells decrease prion-induced glial inflammation in vitro
Scientific Reports, 2022 Prion diseases are characterized by the cellular prion protein, PrPC, misfolding and aggregating into the infectious prion protein, PrPSc, which leads to neurodegeneration and death.
Arielle J. D. Hay +4 more
doaj +1 more source
Sheep scrapie and deer rabies in England prior to 1800
Prion, 2023 Eighteenth-century England witnessed the emergence of two neurological diseases in animals. Scrapie, a transmissible spongiform encephalopathy, is a fatal neurodegenerative disease of sheep and goats that appears in classical and atypical forms.
Anthony Ness +2 more
doaj +1 more source
A New Cell Model for Investigating Prion Strain Selection and Adaptation
Viruses, 2019 Prion diseases are fatal neurodegenerative diseases that affect humans and animals. Prion strains, conformational variants of misfolded prion proteins, are associated with distinct clinical and pathological phenotypes.
Alexandra Philiastides +5 more
doaj +1 more source
Genetic risk factors for Creutzfeldt-Jakob disease
Neurobiology of Disease, 2020 Prion diseases are a group of fatal neurodegenerative disorders of mammals that share a central role for prion protein (PrP, gene PRNP) in their pathogenesis.
Emma Jones, Simon Mead
doaj +1 more source
A multiplexed, paired-pooled droplet digital PCR assay for detection of SARS-CoV-2 in saliva
Scientific Reports, 2023 In response to the SARS-CoV-2 pandemic, we developed a multiplexed, paired-pool droplet digital PCR (MP4) screening assay. Key features of our assay are the use of minimally processed saliva, 8-sample paired pools, and reverse-transcription droplet ...
Kaitlyn Wagner +26 more
doaj +1 more source
Proceedings of the National Academy of Sciences, 1984 Prions are unprecedented infectious pathogens that cause a group of invariably fatal neurodegenerative diseases by an entirely novel mechanism. Prion diseases may present as genetic, infectious, or sporadic disorders, all of which involve modification of the prion protein (PrP).
openaire +3 more sources
Prion, 2023 Prions are misfolded proteins that accumulate within the brain in association with a rare group of fatal and infectious neurological disorders in humans and animals.
Jessy A. Slota +4 more
doaj +1 more source
Post COVID-19 AA amyloidosis of the kidneys with rapidly progressive renal failure
Prion, 2023 Coronavirus disease 2019 (COVID-19) pandemic has taken the world by a storm, posing a gruelling challenge to the medical fraternity globally. Besides its very high infectivityinfectivity, significant organ dysfunction occurs in critically ill COVID-19 ...
Tajamul H. Mir +7 more
doaj +1 more source
Two Chinese patients of sporadic Creutzfeldt–Jacob disease with a S97N mutation in PRNP gene
Prion, 2023 Worldwide, 10–15% human prion disease are genetic and inherited, due to the special mutations or insertions in PRNP gene. Herein, we reported two Chinese patients with rapidly progressive dementia who were referred to the national Creutzfeldt–Jacob ...
Dong-Lin Liang +5 more
doaj +1 more source