Results 141 to 150 of about 2,084,039 (283)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Distribution function of surplus prior to ruin
, 2002 In a study by David Dickson, entitled On the Distribution of Surplus Prior Ruin, presented a method in finding the distribution of surplus prior to ruin with the use of probability of severity of ruin.
Dy, Marie Anne, Meneses, Cathleen
core
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Effect of hyperparameters on the prior distribution.
Effect of hyperparameters on the prior distribution.
Amara Javed (9867557) +2 more
core +1 more source
Prior distribution assessment for a multivariate normal distribution: An experimental study
, 2001 A variety of methods of eliciting a prior distribution for a multivariate normal (MVN) distribution have recently been proposed. This paper reports an experiment in which 16 meteorologists used the methods to quantify their opinions about climatology ...
Al-Awadhi, S. A. +3 more
core +1 more source
Estimation of parameter of proportion in Binomial Distribution Using Adjusted Prior Distribution
پژوهشهای ریاضی, 2017 Historically, various methods were suggested for the estimation of Bernoulli and Binomial distributions parameter. One of the suggested methods is the Bayesian method, which is based on employing prior distribution.
h esfandiari +3 more
doaj
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Detecting Out-of-distribution Data through In-distribution Class Prior [PDF]
Given a pre-trained in-distribution (ID) model, the inference-time out-of-distribution (OOD) detection aims to recognize OOD data during the inference stage.
Jiang, X +6 more
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