Results 41 to 50 of about 385,440 (355)

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Troubles visuo moteurs chez prè maturè et le nourisson de la naissance à 2 ans. evalutation fonctionelle et signes d'alarme. Prise en charge de la malvoyance entre la naissance et 2 ans. [PDF]

, 2008
Corso di formazione SERH " Approches pluridisciplinaires du dèpistage et de la prise en charge sensorimotrice, chez lenfant de la naissance à 2 ans" Reseau Perinatal de la ...
FAZZI, Elisa Maria
core  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Prise en charge de la cirrhose en Médecine générale [PDF]

, 2019
La cirrhose est une pathologie couramment rencontrée en médecine générale. Les étiologies peuvent être variées et sont essentiellement d’origine toxique (alcool…), d’origine métabolique (stéatose non alcoolique : NASH...) ou d’origine infectieuse ...
Paternostre, Sophie, Starkel, Peter, Yombi, Jean Cyr   +2 more
core  

La prise en charge intégrée des maladies de l’enfant comme intervention non médicamenteuse préventive instaurée au sein des structures sanitaires au Gabon [PDF]

Au Gabon, la mortalité infantile revêt une importance capitale pour la santé des enfants. Le taux de mortalité a connu des variations au fil des années, passant de 32,90% en 2020 à 48% en 2021.
Amélie Blanche Ngombo Lepopa
core   +1 more source

The “Gredouno” Cross Target: a new tool adapted to control Glossina palpalis gambiensis in the mangrove forests of Guinea

Parasites & Vectors
Background In the mangroves of Guinea, where the most active foci of human African trypanosomiasis in West Africa are located, vector control against tsetse flies using insecticide-impregnated Tiny Targets was first introduced in 2012.
Kagbadouno Moïse, Camara Abdoulaye Dansy, Bart Jean-Mathieu, Solano Philippe, Bucheton Bruno, Camara Mamadou, Grébaut Pascal   +6 more
doaj   +1 more source

Impact on the Gut Microbiota of Intensive and Prolonged Antimicrobial Therapy in Patients With Bone and Joint Infection

Frontiers in Medicine, 2021
There is a growing interest in the potentially deleterious impact of antibiotics on gut microbiota. Patients with bone and joint infection (BJI) require prolonged treatment that may impact significantly the gut microbiota.
Benoît Levast, Nicolas Benech, Nicolas Benech, Nicolas Benech, Nicolas Benech, Cyrielle Gasc, Cécile Batailler, Cécile Batailler, Cécile Batailler, Eric Senneville, Eric Senneville, Eric Senneville, Sébastien Lustig, Sébastien Lustig, Sébastien Lustig, Cécile Pouderoux, Cécile Pouderoux, David Boutoille, David Boutoille, David Boutoille, Lilia Boucinha, Frederic-Antoine Dauchy, Valérie Zeller, Valérie Zeller, Marianne Maynard, Charles Cazanave, Charles Cazanave, Thanh-Thuy Le Thi, Jérôme Josse, Jérôme Josse, Jérôme Josse, Jérôme Josse, Joël Doré, Frederic Laurent, Frederic Laurent, Frederic Laurent, Frederic Laurent, Tristan Ferry, Tristan Ferry, Tristan Ferry, Tristan Ferry   +40 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Evaluation de la prise en charge de la malnutrition aigue sévère des enfants de 06 à 59 mois à l'URENI du centre de santé de référence de Koutiala en 2014. [PDF]

, 2015
Notre étude a été réalisée à l'URENI du centre de santé de référence de Koutiala. Elle avait pour but d'évaluer la prise en charge de la malnutrition aigue sévère des enfants de 06 à 59 mois à l'URENI du centre de santé de référence de Koutiala.
Diarra, Issa
core  

Antiretroviral treatment response of HIV‐infected children after prevention of mother‐to‐child transmission in West Africa

Journal of the International AIDS Society, 2014
Introduction We assessed the rate of treatment failure of HIV‐infected children after 12 months on antiretroviral treatment (ART) in the Paediatric IeDEA West African Collaboration according to their perinatal exposure to antiretroviral drugs for ...
Camille Ndondoki, Fatoumata Dicko, Patrick Ahuatchi Coffie, Tanoh Kassi Eboua, Didier Koumavi Ekouevi, Kouakou Kouadio, Addi Edmond Aka, Karen Malateste, François Dabis, Clarisse Amani‐Bosse, Pety Toure, Valériane Leroy, for the Paediatric IeDEA West African Working Group   +12 more
doaj   +1 more source