Multiparameter vision testing apparatus [PDF]
, 1975 Compact vision testing apparatus is described for testing a large number of physiological characteristics of the eyes and visual system of a human subject.
Homkes, R. J. +3 more
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
The Effect of Cognitive Style on Individual Differences in Prismatic Adaptation: A Pilot Study
Brain Sciences, 2023 Prism adaptation (PA) is a well-known and widely used technique for rehabilitating unilateral spatial neglect and studying sensory–motor plasticity. However, there is conflicting evidence in the literature regarding its effectiveness which may arise from
Alessia Bonavita +4 more
doaj +1 more source
A scalable parallel finite element framework for growing geometries. Application to metal additive manufacturing [PDF]
, 2019 This work introduces an innovative parallel, fully-distributed finite element framework for growing geometries and its application to metal additive manufacturing.
Ayachit U +10 more
core +2 more sources
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Long-term outcomes of prismatic correction in partially accommodative esotropia.
PLoS ONE, 2019 PurposeIn partially accommodative esotropia (PAET), prism glasses can correct small angles of residual esotropia but the long-term effect of prismatic correction alone without surgery has not been reported.
Hye Rim Choe +2 more
doaj +1 more source
Prism adaptation in alternately exposed hands [PDF]
Attention, Perception, & Psychophysics, 2013 We assessed intermanual transfer of the proprioceptive realignment aftereffects of prism adaptation in right-handers by examining alternate target pointing with the two hands for 40 successive trials, 20 with each hand. Adaptation for the right hand was not different as a function of exposure sequence order or postexposure test order, in contrast with ...
Gordon M, Redding, Benjamin, Wallace
openaire +2 more sources
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Anisotropic Boundary Layer Adaptivity of Multi-Element Wings
, 2014 Multi-element wings are popular in the aerospace community due to their high lift performance. Turbulent flow simulations of these configurations require very fine mesh spacings especially near the walls, thereby making use of a boundary layer mesh ...
Chitale, Kedar C. +4 more
core +1 more source
Metabolic and cardiac adaptation to chronic pharmacologic blockade of facilitative glucose transport in murine dilated cardiomyopathy and myocardial ischemia [PDF]
, 2018 GLUT transgenic and knockout mice have provided valuable insight into the role of facilitative glucose transporters (GLUTs) in cardiovascular and metabolic disease, but compensatory physiological changes can hinder interpretation of these models.
Heitmeier, Monique R. +6 more
core +2 more sources