Results 161 to 170 of about 178,592 (262)

A Novel 3D Model Co‐Culturing Breast Cancer Cells in Direct Contact with Patient‐Derived Mature Adipocytes Demonstrates Cell‐Type Specific Alterations in Phenotype and Chemosensitivity

Advanced Healthcare Materials, EarlyView.
A novel 3D GelMA co‐culture model enabled sustained direct contact between patient‐derived mature adipocytes and breast cancer cells, revealing subtype‐specific interactions. MDA‐MB‐231 co‐culture caused adipocyte perilipin‐1 loss and reduced chemotherapy responsiveness, while MCF7 cells showed partial epithelial‐mesenchymal transition; both cell lines
Jessika A. Wise, Margaret J. Currie, Helen R. Morrin, Gretel S. Major, Tim B. F. Woodfield, Khoon S. Lim, Elisabeth Phillips   +6 more
wiley   +1 more source

Pyrazolate-Bridged PdCo and PdCu Complexes as Dual DNA-Binding and ROS-Driven Cytotoxic Agents. [PDF]

Int J Mol Sci
Uvarova MA, Kulikova VV, Kozmenko YV, Revtovich SV, Filippova AD, Shmelev MA, Sokolova DV, Pokrovsky VS, Kaverina AP, Solyev PN, Eremenko IL.   +10 more
europepmc   +1 more source

Establishment of a Responsive Tooth‐on‐a‐Chip Platform for the Assessment of Regenerative Factors in Dental Tissue Regeneration

Advanced Healthcare Materials, EarlyView.
Using a tooth‐on‐a‐chip model that recreates interactions between dental epithelial and mesenchymal cells, the authors show that sequential FGF10+BMP4, BMP2, and Emdogain produce distinct, biologically consistent regenerative responses. The platform recapitulates known signal‐specific effects and, for the first time, reveals an influence of Emdogain on
Chong Huang, Wei Ji, Fang Yang, X. Frank Walboomers   +3 more
wiley   +1 more source

Differential Assembly of Native Epithelial Sodium Channel Complexes Across Mouse Epithelial Tissues. [PDF]

Kidney360
Bharadwaj A, Curry JN, Curry JN, Su XT, Maturana RB, McCormick JA, Ellison DH, Ellison DH, Baconguis I.   +8 more
europepmc   +1 more source

Artemisinin‐Loaded Core‐Shell Microspheres Modulate Histone Lactylation to Remodel the Microenvironment for Cartilage Protection in Rheumatoid Arthritis

Advanced Healthcare Materials, EarlyView.
ART@PLGA@GH‐A microspheres are developed via microfluidic technology for intra‐articular delivery of artemisinin. The system remodels rheumatoid arthritis microenvironments by regulating metabolic and inflammatory disorders, reducing lactate‐driven histone lactylation and cellular senescence, while restoring cartilage homeostasis and protecting joint ...
Shijie Meng, Jianxin Li, Yuyang Luo, Yisi Liu, Feng Xing, Yingchen Ni, Fengyuan Zhang, Zhicheng Fan, Hua Xu, Weidong Zhang, Youhua Wang   +10 more
wiley   +1 more source

Novel Silver(I) and Gold(I) N-Heterocyclic Carbene Complexes Induce ROS-Dependent Autophagic Cell Death in Human Hepatoma Cell Line HepG2. [PDF]

Chem Biol Drug Des
Miglionico R, Viceconte F, Armentano MF, Mariconda A, Nigro I, Longo P, Bisaccia F.   +6 more
europepmc   +1 more source

Hydrogel‐Based Airway‐on‐Tube With Perfusable Endothelial Lumen and Outward Epithelialization

Advanced Materials, EarlyView.
A hydrogel‐based airway‐on‐tube platform featuring a perfusable endothelial lumen and outward epithelialization is presented. The system supports primary human bronchial epithelial and lung microvascular endothelial coculture under air‐liquid interface conditions.
Ali Doryab, Jack F. Murphy, Michael Bartolf‐Kopp, Jenny C‐C Hsin, Alice Chernaik, Frank McCaughan, Yan Yan Shery Huang, Tomasz Jungst, Jürgen Groll   +8 more
wiley   +1 more source

Integrated Network Pharmacology and Experimental Validation Implicate AKT1-Associated Signaling in the Protective Effects of <i>Panax notoginseng</i> Against Pulmonary Arterial Hypertension. [PDF]

Pulm Circ
Sheng Y, Lu Z, Wang T, Tang H, Liu X, Zhao Z, Rukonge PA, Yu G.   +7 more
europepmc   +1 more source

Phase Engineering of Atomically Precise Nanoclusters (APNCs) of Gold and Beyond

Advanced Materials, EarlyView.
Engineering the structural phase of materials is of paramount importance for both fundamental research and practical applications. In this Review, we summarize the recent progress in controlling the phases of atomically precise nanoclusters (APNCs) of gold, silver and copper, as well as bimetallic systems. The phase‐enabled material properties of APNCs
Yitong Wang, Avirup Sardar, Weijie Ji, Zhongyu Liu, Rongchao Jin   +4 more
wiley   +1 more source

NHC-Au-Xanthate Complexes: Selective Cytotoxic Activity and Mechanistic Insights. [PDF]

ACS Omega
Niemirowicz-Laskowska K, Pietruszyńska M, Chakraborty S, Lipiński PFJ, Kośnik W, Skonieczna B, Misztalewska-Turkowicz I, Car H, Michalak M.   +8 more
europepmc   +1 more source