Results 181 to 190 of about 178,592 (262)

A Synergistic Dual-Antibody Cocktail Targeting α-Toxin Protects Against Invasive <i>Staphylococcus aureus</i> Infection by Neutralizing Virulence and Enhancing Host Defense. [PDF]

MedComm (2020)
Zhao L, Song Z, Fan H, Wang L, Yang Y, Jing H, Xia X, Wang Y, Feng L, Wang S, Chen Z, Gou Q, Yuan Y, Zhang J, Zou Q, Zeng H.   +15 more
europepmc   +1 more source

Programmable Microgel Degradation in Dynamic Granular Hydrogels Guides Extracellular Matrix Assembly During Tissue Repair

Advanced Materials, EarlyView.
This study reports on the chemical modification of hyaluronic acid to create hydrogels with hydrolytic degradability ranging from 2–28 days. Granular hydrogels that undergo timed degradation to increase porosity enhance cell invasion and provisional ECM remodeling in a muscle injury model, leading to reduced fibrosis and improved regeneration ...
Zhiyuan Chen, Tuba Marjan, Xinyue Lu, Nicole E. Mertens, Keira Vesy, Dean E. Stornello, James F. Markworth, Taimoor H. Qazi   +7 more
wiley   +1 more source

Chemical genetic screens combine target dependence with efficacy: discovery of a MAP3K1 degrader (HBC-8) with anticancer activities. [PDF]

Mol Biomed
Umeta LT, Mallareddy JR, Singh S, Vishwakarma K, Kizhake S, Wu W, Kizhake AG, Boghean L, Vishwakarma S, Kachhia M, Sallee AJ, Joshi VS, O'Neill KL, Humphrey-Brattain L, Chee L, Rees MG, Ronan MM, Roth JA, Chatr-Aryamontri A, Bertomeu T, Mohan K, Chen Y, Hewitt K, Mathew G, Black A, Ghosal G, Luo X, Dong J, Woods NT, Natarajan A.   +29 more
europepmc   +1 more source

A Retinal Matrix Stiffening Model Reveals FAK‐Dependent Mechanotransduction in Pericytes Underlies Vascular Destabilization

Advanced Materials, EarlyView.
In this study, we show that retinal matrix stiffness is increased in diabetic mice. Using engineered human vascular models with controlled matrix stiffness, we demonstrate that stiffening activates focal adhesion kinase (FAK) signaling in pericytes, suppresses Notch signaling, and disrupts vascular morphology.
Emily Warren, Alex Wu, Lucas Ramirez, Yaqing Huang, Connor Amelung, Sophia Saxonhouse, Sharon Gerecht   +6 more
wiley   +1 more source

Molecular recognition properties of water-soluble Prism[5]arene towards drugs of abuse. [PDF]

Supramol Chem
Kaur G, Bazan-Bergamino EA, Zhai C, Ashton S, Isaacs L.   +4 more
europepmc   +1 more source

Plasmonically Enhanced Microarray Immunoassay for High‐Sensitivity Monitoring of Heart Failure

Advanced Materials, EarlyView.
A novel plasmonically enhanced PE‐D4 assay combines nanopatch antennas with a microarray immunoassay for the detection of heart failure biomarkers NT‐proBNP, NGAL, and galectin‐3 in complex biological samples. Plasmonic amplification substantially enhances fluorescence signals, enabling sensitive biomarker quantification with a low‐cost smartphone ...
Daria Semeniak, Deniz Acil, Jason Liu, Daniela F. Cruz, Cassio M. Fontes, Chengyang Li, Brooke E. Silverstein, G. Michael Felker, Angus M. Hucknall, Maiken H. Mikkelsen, Ashutosh Chilkoti   +10 more
wiley   +1 more source

FcγRIIA signalling as a host-associated determinant of endosomal trafficking and antibody-dependent enhancement in flavivirus infection. [PDF]

Front Immunol
Rakwi NWWP, Muraoka D, Haga K, Yeo ASL, Moi ML.   +4 more
europepmc   +1 more source

Defined Matrices Reveal Epithelial‐ and Mesenchymal‐Specific Responses to Stiffness and Adhesion in Human iPSC‐Derived Intestinal Organoids

Advanced Materials, EarlyView.
Defined PEG hydrogels enable human iPSC‐derived intestinal organoid culture without Matrigel. PEG‐ and Matrigel‐cultured organoids both support duodenal‐like epithelial identity, but direct comparison reveals subtle epithelial differentiation‐marker shifts and stronger mesenchymal ECM‐remodeling/integrin programs in PEG.
Alicja Kuziola, Tamara Fawzi, Emma H. Kromann, Marion Leleu, Joanna M. Drelinkiewicz, Dusko Ilic, Cécile A. Dreiss, Joana F. Neves, Eileen Gentleman   +8 more
wiley   +1 more source

Structure, Stability, Spectroscopy and Chemical Bonding Analyses on the Novel X₆ (X = N, P, As, Sb, Bi) Molecules. [PDF]

J Comput Chem
Cheng Y, Zhang SW, Dai XY, Zhang YY.
europepmc   +1 more source

A Coaxial Bioprinted Hydrogel With Semipermeable Sheath and Pro‐Chondrogenic Core for Articular Cartilage Repair

Advanced Materials, EarlyView.
A sheath‐core biomimetic hydrogel is engineered with a compartmentalized yet integrated architecture for synergistic multifunctionality. Its stiff, semipermeable sheath mimics the ECM's load‐bearing and protective roles, encapsulating a soft core that provides a pro‐chondrogenic microenvironment similar to the PCM.
Zheyuan Shi, Hua Zhang, Jingying Hu, Guanrong Li, Dianqing Wang, Cuicui Su, Gordon G. Wallace, Qi Gu, Jun Chen, Yingchun Zhu   +9 more
wiley   +1 more source