Results 91 to 100 of about 99,299 (276)
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Elektrotehnìka ta Elektroenergetika, 2019 Purpose. The aim of the work is to create a new method and device for monitoring the integrity of the coupling prisms, which will allow, with minor improvements in the design of individual measuring prisms, to obtain information on the state (damage) of ...
K.A. Kuchynskyi +3 more
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Shock and Vibration, 2017 The energy in flow induced motion (FIM) was harnessed in recent years. In this study, the energy transfer ratio was derived to estimate the energy transference from the flow to the FIM.
Jijian Lian +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Finite element modelling of structural clay brick masonry subjected to axial compression [PDF]
, 2004 This Paper Presents The Numerical Verifications Of The Experimental Investigation On The Effect Of Mortar Joint Thickness On Compressive Strength Characteristics Of Axially Loaded Brick-Mortar Prisms.
Bakhteri, Jahangir +2 more
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Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
E3S Web of Conferences, 2017 The directions of a resource and energy saving when creating a boom-type effectors of roadheaders of selective action with disc rock cutting tools on a multi-faceted prisms for the destruction of formation of minerals and rocks pricemax are presented ...
Manietyev Leonid +3 more
doaj +1 more source
PRISMS: remote high resolution in situ multispectral imaging of wall paintings [PDF]
, 2008 The non-invasive monitoring and examination of wall paintings in grotto sites, tombs and buildings is particularly important since these paintings are often extremely vulnerable. Traditionally, inspection of wall paintings at high resolution (i.e.
Keita, K, Liang, H, Vajzovic, T
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