Results 81 to 90 of about 99,299 (276)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Clinical Optometry, 2017 Pavel Kříž,1 Šárka Skorkovská1,2 1Faculty of Medicine, Department of Ophthalmology and Optometry, Masaryk University, 2Eye Clinic NeoVize Brno, Brno, Czech Republic Purpose: Due to the expansion of modern optotype liquid ...
Kříž P, Skorkovská Š
doaj
Crystals, 2020 A new LED rear light for automotives is proposed and demonstrated for EU ECE R07 regulation. The full rear light is a combination of a position lamp and a braking lamp, and LED light bars and micro-prisms are involved as their essential components.
Hien-Thanh Le +5 more
doaj +1 more source
Study of a composting process in the green waste processing plant [PDF]
, 2019 Composting of sewage sludge together with green waste such as grass, leaves, branches, etc. is carried out in Poland in a number of facilities. A common problem of all compost plant operators is the selection of the type of composting technology and its ...
Pilarski, Grzegorz
core
Identifying combinations of tetrahedra into hexahedra: a vertex based strategy
, 2018 Indirect hex-dominant meshing methods rely on the detection of adjacent tetrahedra an algorithm that performs this identification and builds the set of all possible combinations of tetrahedral elements of an input mesh T into hexahedra, prisms, or ...
Johnen, Amaury +3 more
core +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Optical System Design Method Based on Rotating Risley Prism
IEEE Photonics JournalAs a type of beam steering element, the Risley prism has found extensive applications in the field of optics. A single Risley prism can deflect incident light beams with a constant deviation angle, while a rotating multi-Risley prism system enables ...
Shuaiwei Mu +6 more
doaj +1 more source
Computing the Minkowski sum of prisms [PDF]
Within this paper we compute the Minkowski sum of prisms ("Cephoids") in a finite-dimensional vector space. We provide a representation of a finite sum of prisms in terms of inequalities.convex analysis, Minkowski sum ...
Diethard Pallaschke +1 more
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source