Results 51 to 60 of about 543,621 (317)
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Applied SciencesWhile autonomous driving systems and intelligent transportation infrastructures become increasingly software-defined and network-connected, ensuring their cybersecurity has become a critical component of traffic safety.
Xingyu Wu +8 more
doaj +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
An enhanced DPoS consensus mechanism using quadratic voting in Web 3.0 ecosystem [PDF]
BlockchainConsensus mechanisms are fundamental to maintaining consistency in distributed systems. With the advent of Web 3.0, blockchain has revealed limitations of traditional Delegated Proof of Stake (DPoS) consensus mechanisms.
Tianyu Lei +8 more
doaj +1 more source
, 2019 Privacy loss is central to privacy law scholarship, but a clear definition of the concept remains elusive. We present a model that both captures the essence of privacy loss and can be easily applied to policy evaluations and doctrinal debates. To do so, we use standard Bayesian statistics to formalize a key intuition: that information privacy is ...
Cofone, Ignacio N. N. +1 more
openaire +4 more sources
Proceedings of the 11th International Symposium on Software Engineering for Adaptive and Self-Managing Systems, 2016 Privacy violations in online social networks (OSNs) often arise as a result of users sharing information with unintended audiences. One reason for this is that, although OSN capabilities for creating and managing social groups can make it easier to be selective about recipients of a given post, they do not provide enough guidance to the users to make ...
Calikli, Gul +8 more
openaire +3 more sources
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
IEEE Access, 2018 Android platform has dominated the operating system of mobile devices. However, the dramatic increase of Android malicious applications (malapps) has caused serious software failures to Android system and posed a great threat to users.
Wei Wang +5 more
doaj +1 more source