Results 181 to 190 of about 232,045 (243)

Asymmetric Inter‐Hemisphere Communication Contributes to Speech Acquisition of Toddlers with Cochlear Implants

open access: yesAdvanced Science, EarlyView.
The present study constructs machine‐learning models to resolve developmental relationships among auditory performance, auditory cortical processing, and functional connectivity of the bilateral language network during the first year of restored hearing. The results demonstrate that asymmetric inter‐hemisphere communication contributes significantly to
Xue Zhao   +6 more
wiley   +1 more source

Mechanochemistry: Fundamental Principles and Applications

open access: yesAdvanced Science, EarlyView.
In this review, the physicochemical principles of mechanochemistry are first clarified. Based on this foundation, the research basis and cutting‐edge scientific achievements in four areas are introduced: solid‐state organic chemistry, polymers, interface science, and biomechanochemistry.
Liang Dong   +4 more
wiley   +1 more source

Trait‐Based Life History Strategies Shape Bacterial Niche Breadth

open access: yesAdvanced Science, EarlyView.
This study investigates bacterial niche breadth through a large‐scale soil survey and over 2000 bacterial genomes. It identifies key life‐history traits—growth, competition, stress tolerance, resource acquisition, and dispersal—that correlate with niche breadth.
Ziheng Peng   +8 more
wiley   +1 more source

Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation

open access: yesAdvanced Science, EarlyView.
At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao   +14 more
wiley   +1 more source

GRP78 Nanobody‐Directed Immunotoxin Activates Innate Immunity Through STING Pathway to Synergize Tumor Immunotherapy

open access: yesAdvanced Science, EarlyView.
A GRP78 nanobody‐directed immunotoxin suppresses cancer progression and metastasis by enhancing antitumor immunity via STING pathway activation, offering a pan‐cancer‐targeted approach and immunotherapy combination strategy. Abstract The lack of targetable antigens poses a significant challenge in developing effective cancer‐targeted therapies.
Huifang Wang   +16 more
wiley   +1 more source

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