Results 61 to 70 of about 1,065,424 (332)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Prochlo: Strong Privacy for Analytics in the Crowd

, 2017
The large-scale monitoring of computer users' software activities has become commonplace, e.g., for application telemetry, error reporting, or demographic profiling. This paper describes a principled systems architecture---Encode, Shuffle, Analyze (ESA)--
Abadi M., Abadi M., Abadi M., Avent B., Bellare M., Bulck J. V., Buse R. P. L., Chen R., Corrigan-Gibbs H., Dang H., Denning D. E. R., Dinh T. T. A., Dwork, Lee S., Maniatis P., Ohrimenko O., Ravindranath L., Roy I., Saltzer J. H., Viega J., Wang T., Warner, Zheng W.   +22 more
core   +1 more source

Linear and Range Counting under Metric-based Local Differential Privacy

, 2020
Local differential privacy (LDP) enables private data sharing and analytics without the need for a trusted data collector. Error-optimal primitives (for, e.g., estimating means and item frequencies) under LDP have been well studied.
Ding, Bolin, He, Xi, Xiang, Zhuolun, Zhou, Jingren   +3 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Privacy by Design

, 2018
Digital identification systems, integrated with civil registration, can play a transformational role across many development areas, such as financial inclusion, expanding access to services and social safety nets, and effective humanitarian response.
  +5 more sources

Privacy designs, technological sovereignty and digital pandemic response-ability

Journal of Responsible Innovation
This article tells the story of digital contact tracing in Norway and ensuing public controversies over encompassing surveillance. The resolution of the controversy came to turn predominantly on matters of privacy and measures provided through privacy-by-
Niels Van Dijk, Kjetil Rommetveit, Maciej Otmianowski   +2 more
doaj   +1 more source

In/Visible Bodies. On patients and privacy in a networked world [PDF]

, 2012
In the networked world, privacy and visibility become entangled in new and unexpected ways. This article uses the concept of networked visibility to explore the entanglement of technology and the visibility of patient bodies.
van der Velden, Maja
core  

Analysis of The Effect of Reliability, Privacy and Security, Website Design, Customer Service and Support, and Satisfaction towards Loyalty of Livin’ by Mandiri users in Medan [PDF]

, 2023
Eleaner Eleaner, Ronald Ronald, Amelia Amelia   +2 more
openalex   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source