Results 111 to 120 of about 38,942 (309)
Rewarding Sequential Innovators: Patents Prizes and Buyouts [PDF]
This paper presents a model of cumulative innovation where firms are heterogeneous in their research ability. We study the optimal reward policy when the quality of the ideas and their subsequent development effort are private information.
Matthew Mitchell
core
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Deterrence in Rank-Order Tournaments [PDF]
In a tournament, competitors may engage in undesirable activities, or 'cheating', in order to gain an advantage. Examples of such activities include the taking of steroids, plagiarism, and 'creative accounting'.
Philip A. Curry, Steeve Mongrain
core
Statistical Framework: Estimating the Cumulative Shares of Nobel Prizes from 1901 to 2022
StatsStudying trends in the geographical distribution of the Nobel Prize is an interesting topic that has been examined in the academic literature. To track the trends, we develop a stochastic estimate for the cumulative shares of Nobel Prizes awarded to ...
Xu Zhang, Bruce Golden, Edward Wasil
doaj +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Prizes and Incentives in Elimination Tournaments [PDF]
The role of rewards for maintaining performance incentives in multistage, sequential games of survival is studied. The sequential structure is a statistical design-of-experiments for selecting and ranking contestants.
Sherwin Rosen
core
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source