Treatment Effects on Chronic Active Lesions in Multiple Sclerosis: Current Evidence and Future Perspectives. [PDF]
Neurol TherPreziosa P +3 more
europepmc +1 more source
Silymarin and Its Isolated Flavanonol Lignans Are Liver X Receptor Antagonists
Archiv der Pharmazie, Volume 359, Issue 6, June 2026.Despite its long tradition in the treatment of liver‐related ailments, the precise mode of action of the milk thistle fruit extract remains vague. Here we identified liver X receptor as a molecular target of silymarin, a mixture of bioactive compounds from milk thistle extract, and its major flavanonol lignan components, which account for their anti ...
Nils C. Bandomir +3 more
wiley +1 more source
Dopamine D2 and GABA(A) Receptors Differentially Regulate Ethanol-Induced Aversion and Reward Through Corticolimbic Circuits. [PDF]
Int J Mol SciWu CE +6 more
europepmc +1 more source
Biological Reviews, Volume 101, Issue 3, Page 1463-1478, June 2026.ABSTRACT Human life history is derived compared to that of our closest living relatives, the great apes. It has been suggested that these derived traits are causally related to aspects of our ecology, social behaviour and cognitive abilities. However, resolving this requires that we know the evolutionary trajectory of our distinctive pattern of growth,
Paola Cerrito +2 more
wiley +1 more source
Vitamin D Adequacy Conditions the Prolactin-Suppressive Effect of Metformin in Men Receiving Prolactin-Elevating Medications. [PDF]
NutrientsKrysiak R +4 more
europepmc +1 more source
Contemporary European Politics, Volume 4, Issue 2, June 2026.ABSTRACT Following a breakdown in the post‐1989 liberal consensus that governed Polish democracy promotion in its eastern neighbours under Law and Justice's term from 2015, we can expect policy changes to Polish democracy promotion. Paying tribute to historical explanations of Poland's democracy promotion, this article links the historical legacies of ...
Wicke van den Broek
wiley +1 more source
circOMA1 delivered by exosomes regulates DRD2‑mediated prolactinoma resistance. [PDF]
Int J Mol MedRao Q +9 more
europepmc +1 more source
Super‐enhancer‐driven KIAA1522 upregulation suppresses ferroptosis in hepatocellular carcinoma
Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.Critical points: Aberrantly activated SEs drive the overexpression of the oncogene KIAA1522 in HCC. Targeting SEs and knocking down KIAA1522 facilitate ferroptosis in HCC. As a key downstream effector of KIAA1522, ATF4 plays an essential regulatory role in ferroptosis mediated by the oncoprotein. Abstract Background Aberrantly activated super‐enhancers
Xinyang Li +5 more
wiley +1 more source
Metabolic changes in normal-appearing white matter associate with MRI measures of disease burden in relapsing-remitting multiple sclerosis over three years. [PDF]
Sci RepZöchner A +6 more
europepmc +1 more source
Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.EV‐derived miR‐941 as a key driver of anlotinib resistance via the Keap1/Nrf2 pathway represent a promising non‐invasive predictive biomarker and a potential therapeutic target for overcoming resistance in NSCLC. Abstract Background Anlotinib is a multitargeted tyrosine kinase inhibitor for the treatment of advanced non‐small cell lung cancer (NSCLC ...
Aimi Huang +5 more
wiley +1 more source