Results 91 to 100 of about 170,345 (285)
Cadernos de Estudos Lingüísticos, 2011 The aim of this paper is to syntactically derive the interpretative parallelism between SV sentences in null subject languages and Left-Dislocation constructions (LD) in Brazilian Portuguese (BP) and French.
Helena Britto
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Toward a uniform account of scrambling and clitic doubling [PDF]
, 2008 A commonly held view in the literature on Scrambling and Clitic Doubling is that both constructions are sensitive to Specificity. For this reason Sportiche (1992) proposes to unify the two, an approach which has become quite standard in the relevant ...
Alexiadou, Artemis +1 more
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Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Overt and Null Subject Variation in Ammani Arabic: Distribution, Constraints, and Implications
ПсихолінгвістикаPurpose. This article investigates the distribution of overt and null subject pronouns in Ammani Arabic (AA) from a variationist perspective, identifying social and linguistic constraints that shape pronoun expression. The study examines how age, gender,
Рахаф Хатер +3 more
doaj +1 more source
Improving treebank-based automatic LFG induction for Spanish [PDF]
, 2006 We describe several improvements to the method of treebank-based LFG induction for Spanish from the Cast3LB treebank (O’Donovan et al., 2005). We discuss the different categories of problems encountered and present the solutions adopted.
Chrupała, Grzegorz, van Genabith, Josef
core
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Pro-drop and subject pronouns in Assamese
International Journal of Linguistics, Literature and Translation, 2020 In recent years a considerable attention has been given to the study of control and pro-drop. Languages with rich agreement patterns allow for phonetically empty subject which is called “pro”. This paper deals with the pro-drop phenomena of Assamese.
openaire +2 more sources
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source