Results 101 to 110 of about 2,016,145 (275)
Revista do GEL, 2005 A lingua materna (LM) deixa marcas inevitáveis na interlíngua de aprendizes de uma lingua estrangeira (LE). 0 input recebido e a conscientização das diferenças entre as línguas são fundamentais no desenvolvimento da LE.
Ana Paula Marques Beato Canato +1 more
doaj
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Revista do GEL, 2014 A lingua materna (LM) deixa marcas inevitáveis na interlíngua de aprendizes de uma lingua estrangeira (LE). 0 input recebido e a conscientização das diferenças entre as línguas são fundamentais no desenvolvimento da LE.
Ana Paula Marques Beato Canato +1 more
doaj
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
ENGLISH AS A PRO-DROP LANGUAGE
ENGLISH AS A PRO-DROP LANGUAGESince Rizzi's (1986) seminal work on phonologically null pronominals, how to derive the classification of the so-called pro-drop languages has long been controversial in the literature. Various alternative proposals emerged, and we have gained some understanding of some nontrivial generalizations behind the phenomenon, and a number of interesting ...
openaire +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Speaker subject expression with verbs of cognition – think/believe in Italian and Spanish
Borealis: An International Journal of Hispanic LinguisticsIn this paper, we study 1st person subject pronoun realization with verbs of cognition in spoken Spanish and Italian corpus data. Previous studies have shown particularly frequent overt subjects with 1st person singular (yo) creo ‘(I) think/believe’ in ...
Peter Herbeck +2 more
doaj +1 more source