Results 91 to 100 of about 2,016,145 (275)
O parâmetro Pro-drop e a aquisição de segunda língua
Semina: Ciências Sociais e Humanas, 1988 Within the Government and Binding theory (GB), it is assumed the man is equipped with some innate language structure, Universal Grammar (UG), which contains a set of inviolable principles plus some open parameters which are set by experience.
Sonia Maria Lazzarini Cyrino
doaj
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Pedagogika, 2016 Abstrakt Jedním z faktorů ovlivňujících kvalitu vzdělávání je nedostatek učitelů, způsobený mj. vzrůstající mírou odchodů učitelů z profese, tzv. drop-outem. Nejohroženější profesní skupinou jsou přitom učitelé - novicové.
Michaela Píšová, Světlana Hanušová
doaj
Infant bilingualism and the Pro-drop parameter
, 1999 No research has been done to assess the occurrence of null and overt subjects in young bilinguals simultaneously acquiring a [+pro-drop] and a [-pro-drop] language. Previous research indicates that monolinguals set the pro-drop parameter at a very early age.
openaire +2 more sources
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Canadian Journal of Applied Linguistics, 2015 Numerous studies, examining the acquisition of non-referential it in [-pro-drop] English by learners of [+pro-drop] languages, have revealed that their participants omit non-referential subjects in English if their L1 allows null-subject position ...
Elena Antonova-Ünlü
doaj
Experiencers at the syntax-pragmatics interface. The case of the jo ‘I’ – construction in Catalan
GlossaThis paper aims to support the thesis that Speech Act related operators have landing sites in syntax, specifically at the syntax-pragmatics interface. In order to attain this goal, it presents the first formal analysis of a construction, dubbed the jo ‘I’
M.Teresa Espinal, Sonia Cyrino
doaj +2 more sources
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source