Results 131 to 140 of about 961,325 (300)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Exploring the Trade-Off Between Materialism and Pro-Environmental Behavior Through the Lens of Narcissism

open access: yesBusinesses
This study investigates the relationship between materialism and pro-environmental behavior, focusing on the moderating role of narcissism in the attitude–behavior gap.
Linas Pupelis, Beata Šeinauskienė
doaj   +1 more source

Competitive Altruism and Endogenous Reference Group Selection in Private Provision of Environmental Public Goods [PDF]

open access: yes, 2012
We develop and test a model of social comparison in which individuals gain status through pro-social behavior (competitive altruism) and in which they endogenously choose the reference group and associated reference standard involved in signaling status (
Kühling, Jan, Welsch, Heinz
core  

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

Pro-environmental behavior : On the interplay of intrinsic motivations and external conditions [PDF]

open access: yes, 2017
A key issue for ecological economics concerns the processes whereby people engage in ecologically responsible behavior and contribute to environmental quality even when they involve a personal cost for a shared benefit.
Padilla, Emilio, Silvi, María Teresa
core  

Strength through diversity: how cancers thrive when clones cooperate

open access: yesMolecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken   +3 more
wiley   +1 more source

ENVIRONMENTAL LITERACY IN MIDDLE SCHOOL: ECOLOGICAL KNOWLEDGE, COGNITIVE SKILLS, ENVIRONMENTAL AFFECT, AND PRO-ENVIRONMENTAL BEHAVIOR

open access: yesJurnal Eduscience
Purpose-The research examines the environmental literacy of the VIII grade students of SMP Negeri 1 Banawa based on four principal indicators: ecological knowledge, cognitive skills, environmental affect, and pro-environmental behavior. The research aims
Nurasyah Dewi Napitupulu   +5 more
doaj   +1 more source

More “Nudging” for pro-environmental behavior

open access: yesInternational Journal of Behavior Studies in Organizations, 2020
The effects of global warming became aware for every one during the last years. Most of the scientists support the opinion that the partly rough changes in the climate and the pollution of the planet are closely related to the behavior of the peoples around the world.
openaire   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Energy Policy Options - from the Perspective of Public Attitudes and Risk Perceptions [PDF]

open access: yes
In the present study a representative sample (N = 797) of the Swedish population was surveyed, with regard to attitudes related to energy policy issues (e.g., environmental attitudes, risk perceptions, and attitudes towards different energy production ...
Viklund, Mattias
core  

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