Results 131 to 140 of about 133,914 (295)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

COVID-19 and Pro-environmental Behaviour at Destinations Amongst International Travellers. [PDF]

Front Psychol, 2022
Calder G, Radic A, Ryu HB, Ariza-Montes A, Han H.   +4 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Barriers and facilitators for pro-environmental behavior

, 2013
To what extent we as individuals and members of a household live a sustainable life depends on the choices we make in our everyday life. This means that the products we consume, the way we travel, the kind of appliances we use in our household, and the ...
Garvill, Jörgen,, Eriksson, Louise,, Nordlund, Annika,   +2 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Promoting pro-social behaviour

, 2019
In this chapter we will: - Understand the aim of a proactive approach to classroom behaviour management with respect to promoting pro-social behaviours in the primary school years; - Explore theoretical perspectives of contemporary classroom behaviour ...
McLennan, Brad, Peel, Karen
core  

Corporate Social Responsibility and Energy-Related Pro-Environmental Behaviour of Employees in Hospitality Industry. [PDF]

Int J Environ Res Public Health, 2022
Zhang H, Omhand K, Li H, Ahmad A, Samad S, Gavrilut D, Badulescu D.   +6 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Environmental and Pro-Social Norms: Evidence from 30 Countries [PDF]

The paper investigates the relationship between pro-social norms and its implications for improved environmental outcomes, an area which has been neglected in the environmental economics literature.
Benno Torgler, Bruno S. Frey, Clevo Wilson   +2 more
core  

Why Employees Contribute to Pro-Environmental Behaviour: The Role of Pluralistic Ignorance in Chinese Society

, 2019
In light of the importance of sustainable development, this study aims to deepen and extend our understanding of employees’ pro-environmental behaviour in the workplace in a Chinese context.
Kai-Jun Sun, Jia-Wen Shi, Hao-Fan Chumg
core   +1 more source