Results 121 to 130 of about 3,051,760 (306)

Cytokine production patterns in patients with sickle cell disease and avascular necrosis of the femoral head

open access: yesPediatric Hematology Oncology Journal
Background: An imbalance in pro- and anti-inflammatory cytokines has been suggested to contribute to tissue damage in sickle disease (SCD) following recurrent ischemia, which leads to several complications including avascular necrosis (AVN) of the ...
Fawaz Azizieh   +7 more
doaj   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

open access: yesFEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito   +7 more
wiley   +1 more source

Immune regulation is more effective in the U937 inflammation model with mesenchymal stem cell extracellular vesicles stimulated by pro-inflammatory cytokines

open access: yes
Mesenchymal stem cells (MSCs), which are multipotent adult cells with many therapeutic effects, can be derived from stromal tissues. MSCs also exert immunoregulatory effects through extracellular vesicles (EVs), cell membrane structures that carry ...
Canan Öztürk   +3 more
core   +1 more source

Expression of pro-inflammatory cytokines in the BCP group compared to the Oil group.

open access: yes, 2019
Expression of pro-inflammatory cytokines in the BCP group compared to the Oil group.
Milos V. Novotny (1890157)   +8 more
core   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

open access: yesFEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda   +4 more
wiley   +1 more source

Pro-inflammatory cytokines IL-1ß and TNF-a are not associated with plasma homocysteine concentration in Alzheimer's disease

open access: yes, 2013
Increased concentrations of pro-inflammatory blood cytokines and plasma homocysteine (Hcy) are frequently reported in Alzheimer's disease (AD). Hcy appears to have immunomodulating and pro-inflammatory activities.
Gary Weaving (16063532)   +6 more
core   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

open access: yesFEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain   +11 more
wiley   +1 more source

Pro-inflammatory cytokines downregulate 5-MTP production.

open access: yes, 2016
(A) Measurement of 5-MTP in HUVEC-CM by ELISA. HUVECs were treated with VEGF or pro-inflammatory cytokines for 24 hours. H2O denotes deionized water, Medium, control medium and cont, vehicle control. * indicates P P < .05 compared to control.
Yi-Fu Wang (1915039)   +4 more
core   +1 more source

Pro-inflammatory cytokines IL-1ß and TNF-aa are not associated with plasma homocysteine concentration in Alzheimer's disease

open access: yes, 2013
Increased concentrations of pro-inflammatory blood cytokines and plasma homocysteine (Hcy) are frequently reported in Alzheimer's disease (AD). Hcy appears to have immunomodulating and pro-inflammatory activities.
Gary Weaving (16063532)   +6 more
core   +1 more source

The alterations of molecular repertoire of the RANKL-induced osteoclastogenesis in the M1 macrophage-derived inflammatory milieu

open access: yesScientific Reports
Inflammation have been linked to bone diseases such as osteoporosis or bone destruction. However, whether M1 inflammatory stimuli exert a stimulatory or inhibitory effect on the differentiation of osteoclasts remained controversial.
Chun-Shan Wu   +6 more
doaj   +1 more source

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