Results 31 to 40 of about 25,483,142 (313)

Results of the Childhood Cancer and Leukaemia Group's United Kingdom Relapsed Wilms Tumour Trial

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background The United Kingdom relapsed Wilms tumour (UKW‐R) trial aimed to improve the historically low survival rates after relapse of Wilms tumour (WT) through a prospective national risk‐stratified protocol. The trial also evaluated efficacy and toxicity of high‐dose melphalan.
Sucheta J. Vaidya, Veronica Moroz, Juliet Hale, Vesna Pavasovic, Rachel Hobson, Patricia Sartori, Daniel Saunders, Mark Powis, Gordan M. Vujanic, Stephen Baker, Kathy Pritchard‐Jones   +10 more
wiley   +1 more source

Probabilistic Analysis of Rainfall-Induced Slope Stability Using KL Expansion and Polynomial Chaos Kriging Surrogate Model

Geosciences
Rainfall infiltration is one of the main factors inducing slope instability, while the spatial heterogeneity and uncertainty of soil parameters have profound impacts on slope response characteristics and stability evolution.
Binghao Zhou, Kepeng Hou, Huafen Sun, Qunzhi Cheng, Honglin Wang   +4 more
doaj   +1 more source

Safety factor for flaw evaluation of a pipe having a circumferential surface flaw

Nihon Kikai Gakkai ronbunshu, 2015
In order to prevent failure of piping, limitation on flaw depth according to the circumferential flaw angle is prescribed in the Fitness-For-Service Codes (FFS Codes) of the Japan Society of Mechanical Engineers (JSME).
Hideo MACHIDA, Manabu ARAKAWA
doaj   +1 more source

Effect of Precompression and Material Uncertainty on the In-Plane Behavior of URM Pier–Spandrel Systems

Buildings, 2023
Theoretical and experimental studies on loadbearing masonry walls have shown the significant influence of the axial load level (i.e., precompression) and wall aspect ratio on in-plane lateral resistance.
Bora Pulatsu, Semih Gonen, Fulvio Parisi
doaj   +1 more source

A PRSZT Registry Analysis of Prognostic Factors Influencing Survival and Relapse Rates After Second Allogeneic Hematopoietic Stem Cell Transplantation in Pediatric Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT A second allogeneic (allo‐)hematopoietic stem cell transplantation (HSCT2) is a potential curative option for pediatric patients with acute lymphoblastic leukemia (ALL) following relapse after first allogeneic transplantation (HSCT1), but its efficacy is limited by high relapse rates and transplant‐related toxicity in highly pretreated ...
Ava Momm, Imme Haubitz, Rita Beier, Martin Zimmermann, Andrej Lissat, Peter Bader, Matthias Eyrich, Jan‐Henning Klusmann, Matthias Wölfl, Paul‐Gerhardt Schlegel, Verena Wiegering   +10 more
wiley   +1 more source

Computational modelling of random distribution of stresses for wooden structures [PDF]

Инженерно-строительный журнал, 2017
Stochastic allocation is the main characteristic of processes which can be described in wooden structures. Random distribution of stresses and deformations in such structures is mostly based on timber imperfections, such as different curvature of sticks,
I.K. Rasha, O.N. Pertseva, A.Yu. Lazareva, G.V. Martynov   +3 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Assessing Submarine Slope Stability through Deterministic and Probabilistic Approaches: A Case Study on the West-Central Scotia Slope

Geosciences, 2018
A simplified geostatistical approach was adopted to assess the effect of spatial variability of soil properties on slope stability analysis in order to understand continental margin geologic processes and potential geohazards for an area of the central ...
Kevin MacKillop, Gordon Fenton, David Mosher, Valerie Latour, Perry Mitchelmore   +4 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source