Results 221 to 230 of about 493,090 (289)

The future of precision orthopaedics: personalized data-driven practice. [PDF]

open access: yesBone Jt Open
Kader DF   +4 more
europepmc   +1 more source

High‐Asymmetry Metasurface: A New Solution for Terahertz Resonance via Active Learning‐Augmented Diffusion Model

open access: yesAdvanced Science, EarlyView.
A prior knowledge‐guided diffusion model augmented by physics‐constrained active learning is developed to design high‐asymmetry terahertz metamaterials. Trained on only a small set of classical structures, the model efficiently generates new high‐metrics designs.
Qiqi Dai   +7 more
wiley   +1 more source

SpaBatch: Deep Learning‐Based Cross‐Slice Integration and 3D Spatial Domain Identification in Spatial Transcriptomics

open access: yesAdvanced Science, EarlyView.
SpaBatch is an end‐to‐end multi‐slice spatial transcriptomics data integration framework. It simultaneously performs embedding learning, spatial feature denoising and reconstruction, batch effect correction, and spatial domain optimization, effectively correcting batch effects and achieving accurate 3D spatial domain identification.
Jinyun Niu   +5 more
wiley   +1 more source

Computational challenges and solutions: Prime number generation for enhanced data security. [PDF]

open access: yesPLoS One
Ezz-Eldien A   +6 more
europepmc   +1 more source

Dynamic Synthesis of Multi‐Modal Representations for CITE‐seq Data Integration and Analysis

open access: yesAdvanced Science, EarlyView.
The accurate integration of CITE‐seq modalities faces challenges due to complex RNA‐protein nonlinear interactions and computational inefficiencies. A lightweight framework that adaptively fuses RNA and ADT modalities, and refines them through fine‐grained learning is developed to address this issue.
Yinan Shi   +5 more
wiley   +1 more source

Enhancer Reprogramming Reveals the Tumorigenic Role of PTPRZ1 in Lung Squamous Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
Lung squamous cell cancer (LUSC) is deadly due to lack of good treatments. Here, multiomics techniques are applied to LUSC tumors and find thousands of cancer‐specific enhancers controlling key genes. Interestingly, the gene PTPRZ1 is identified as a critical oncogene driven by the LUSC‐acquired enhancers. PTPRZ1 is activated by MDK, fueling cancer via
Yong‐Qiang Ning   +11 more
wiley   +1 more source

Nonalcoholic Fatty Liver Disease Exacerbates the Advancement of Renal Fibrosis by Modulating Renal CCR2+PIRB+ Macrophages Through the ANGPTL8/PIRB/ALOX5AP Axis

open access: yesAdvanced Science, EarlyView.
The ANGPTL8/PIRB/ALOX5AP axis mediates liver‐kidney crosstalk. Hepatocytes secrete ANGPTL8, which binds to CCR2+PIRB+ macrophages in the kidneys, affecting the expression of ALOX5AP and enhancing the activation of these macrophages. Activated cells produce TGF‐β, IL‐6, and IL‐23, driving Th17 activation and promote the formation of myofibroblasts ...
Shuqi Wei   +18 more
wiley   +1 more source

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