Results 61 to 70 of about 151,404 (250)

A geometric characterisation of sensitivity analysis in monomial models

open access: yes, 2018
Sensitivity analysis in probabilistic discrete graphical models is usually conducted by varying one probability value at a time and observing how this affects output probabilities of interest. When one probability is varied then others are proportionally
Leonelli, Manuele, Riccomagno, Eva
core   +2 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Learned graphical models for probabilistic planning provide a new class of movement primitives

open access: yesFrontiers in Computational Neuroscience, 2013
Biological movement generation combines three interesting aspects: itsmodular organization in movement primitives, its characteristics ofstochastic optimality under perturbations, and its efficiency in termsof learning.
Elmar A. Rückert   +3 more
doaj   +1 more source

Parametric Modelling of Multivariate Count Data Using Probabilistic Graphical Models [PDF]

open access: yes, 2013
Multivariate count data are defined as the number of items of different categories issued from sampling within a population, which individuals are grouped into categories.
Durand, Jean-Baptiste   +2 more
core   +2 more sources

Frailty Exacerbates Disability in Progressive Multiple Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background To evaluate frailty in severe progressive multiple sclerosis (PMS) and to investigate the underlying mechanisms. Methods This prospective, cross‐sectional, multicenter study enrolled a late severe PMS group requiring skilled nursing (n = 53) and an age, sex, and disease duration‐matched control PMS group (n = 53).
Taylor R. Wicks   +10 more
wiley   +1 more source

Baseline Regional Cholinergic Denervation Predicts Cognitive Trajectories in Moderate Parkinson Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive decline is a disabling and variable feature of Parkinson disease (PD). While cholinergic system degeneration is linked to cognitive impairments in PD, most prior research reported cross‐sectional associations. We aimed to fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ...
Taylor Brown   +6 more
wiley   +1 more source

SNPest: a probabilistic graphical model for estimating genotypes [PDF]

open access: yesBMC Research Notes, 2014
As the use of next-generation sequencing technologies is becoming more widespread, the need for robust software to help with the analysis is growing as well. A key challenge when analyzing sequencing data is the prediction of genotypes from the reads, i.e. correct inference of the underlying DNA sequences that gave rise to the sequenced fragments.
Lindgreen, Stinus   +2 more
openaire   +5 more sources

Development of a Personalized Visualization and Analysis Tool to Improve Clinical Care in Complex Multisystem Diseases With Application to Scleroderma

open access: yesArthritis Care &Research, EarlyView.
Objective In complex diseases, it is challenging to assess a patient's disease state, trajectory, treatment exposures, and risk of multiple outcomes simultaneously, efficiently, and at the point of care. Methods We developed an interactive patient‐level data visualization and analysis tool (VAT) that automates illustration of the trajectory of a ...
Ji Soo Kim   +18 more
wiley   +1 more source

Hydroxychloroquine Associated With Lower Glomerular Filtration Rate Decline in Lupus Nephritis

open access: yesArthritis Care &Research, EarlyView.
Objective Hydroxychloroquine (HCQ) protects kidney function in lupus nephritis (LN) by preventing flares, yet some cohort studies show no significant benefit in kidney function with HCQ. Clarifying these conflicting findings by showing early and long‐term benefits of HCQ on kidney function preservation is critical.
Shivani Garg   +9 more
wiley   +1 more source

COMPUTATIONALLY EFFICIENT ASSESMENT OF FIGHTER AIRCRAFT MISSION SURVIVABILITY WITH PROBABILISTIC GRAPHICAL MODELS

open access: yesHavacılık ve Uzay Teknolojileri Dergisi, 2017
This paper proposes a probabilistic model for assessment of fighter aircraft mission survivability. Mission survivability analysis is a critical phase for both design of the fighter aircraft and evaluation of its performance.
Nazım Kemal Üre
doaj  

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