Results 51 to 60 of about 90,397 (281)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Coupled Fixed Point Theory over Quantale-Valued Quasi-Metric Spaces (QVQMS) with Applications in Generalized Metric Structures

Axioms
In this study, we establish several coupled fixed point results in quantale-valued quasi-metric spaces (QVQMSs), which constitutes a generalization of metric and probabilistic metric spaces. The obtained results will be illustrated with concrete examples.
Irem Eroğlu
doaj   +1 more source

Some fixed point results in Menger spaces using a control function [PDF]

Surveys in Mathematics and its Applications, 2009
Here we prove a probabilistic contraction mapping principle in Menger spaces. This is in line with research in fixed point theory using control functions which was initiated by Khan et al. [Bull. Austral. Math.
Krishnapada Das, Binayak S. Choudhury, P.N. Dutta   +2 more
doaj  

Statistical convergence in probabilistic generalized metric spaces w.r.t. strong topology

Journal of Inequalities and Applications, 2021
In this paper, the concept of probabilistic g-metric space with degree l, which is a generalization of probabilistic G-metric space, is introduced. Then, by endowing strong topology, the definition of l-dimensional asymptotic density of a subset A of N l
Rasoul Abazari
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Symmetric Spaces and Fixed Points of Generalized Contractions

Abstract and Applied Analysis, 2014
Some fixed point results in semi-metric spaces as well as in symmetric spaces are proved. Applications of our results to probabilistic spaces are also presented.
Sarah Alshehri, Ivan Aranđelović, Naseer Shahzad   +2 more
doaj   +1 more source

Functional-Type Caristi–Kirk Theorem on Menger Space and Application

Journal of Mathematics, 2020
In this paper, we extend Caristi’s fixed point theorem in metric spaces to probabilistic metric spaces, and also, we prove some common fixed point theorems for a pair of mappings satisfying a system of Caristi-type contractions in the setting of a Menger
Soumia Chaira, Mohammed Dahmouni, Abderrahim Eladraoui, Mustapha Kabil   +3 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

The complexity probabilistic quasi-metric space

Journal of Mathematical Analysis and Applications, 2011
The authors acknowledge the support of the Spanish Ministry of Science and Innovation under grant MTM2009-12872-C02-01.
Romaguera, Salvador, Tirado, Pedro
openaire   +7 more sources