Results 71 to 80 of about 77,307 (275)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

A Novel Multi-Level Constellation Compression Modulation for GFDM-PON

IEEE Photonics Journal, 2019
In this paper, for the first time, a novel multi-level constellation compression modulation (MCCM) is proposed and applied for generalized frequency division multiplexing passive optical network (GFDM-PON).
Lei Jiang, Bo Liu, Yaya Mao, Xiangyu Wu, Jianxin Ren, Xing Xu, Shun Han, Jianye Zhao, Lilong Zhao, Tingting Sun, Lijia Zhang   +10 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Enhanced PON and AMCC Joint Transmission with GMM-Based Probability Shaping Techniques

Photonics
In ITU-T standards, auxiliary management and control channels (AMCCs), as defined, facilitate the rapid deployment and efficient management of wavelength division multiplexing passive optical network (WDM-PON) systems.
Haipeng Guo, Chuanchuan Yang, Zhangyuan Chen, Hongbin Li   +3 more
doaj   +1 more source

26.8-m THz wireless transmission of probabilistic shaping 16-QAM-OFDM signals

APL Photonics, 2020
Recently, remarkable efforts have been made in developing wireless communication systems at ultrahigh data rates, with radio frequency (RF) carriers in the millimeter wave (30–300 GHz) and/or in the terahertz (THz, >300 GHz) bands. Converged technologies
Shiwei Wang, Zijie Lu, Wei Li, Shi Jia, Lu Zhang, Mengyao Qiao, Xiaodan Pang, Nazar Idrees, Muhammad Saqlain, Xiang Gao, Xiaoxiao Cao, Changxing Lin, Qiuyu Wu, Xianmin Zhang, Xianbin Yu   +14 more
doaj   +1 more source

Bit-Metric Decoding of Non-Binary LDPC Codes with Probabilistic Amplitude Shaping

, 2018
A new approach for combining non-binary low-density parity-check (NB-LDPC) codes with higher-order modulation and probabilistic amplitude shaping (PAS) is presented.
Böcherer, Georg, Liva, Gianluigi, Steiner, Fabian   +2 more
core   +1 more source

ProDAS: Probabilistic Dataset of Abstract Shapes

, 2023
We introduce a novel and comprehensive dataset, named ProDAS, which enables the generation of diverse objects with varying shape, size, rotation, and texture/color through a latent factor model. ProDAS offers complete access and control over the data generation process, serving as an ideal environment for investigating disentanglement, causal discovery,
Müller, Jens, Ardizzone, Lynton, Köthe, Ullrich   +2 more
openaire   +2 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source