Results 51 to 60 of about 514,307 (282)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

A novel probabilistic model with properties: Its implementation to the vocal music and reliability products

Alexandria Engineering Journal
So far in the literature, numerous probabilistic models and families of probabilistic models have been suggested and put into practice. A large portion of these probabilistic models are developed and updated by introducing new parameters ranging up to ...
Yingying Qi, Dan Ding, Yusra A. Tashkandy, M.E. Bakr, M.M. Abd El-Raouf, Anoop Kumar   +5 more
doaj   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Modeling and control of an unstable system using probabilistic fuzzy inference system

Archives of Control Sciences, 2015
A new type Fuzzy Inference System is proposed, a Probabilistic Fuzzy Inference system which model and minimizes the effects of statistical uncertainties.
Sozhamadevi N., Sathiyamoorthy S.
doaj   +1 more source

Assessing impending hazards from summit eruptions: the new probabilistic map for lava flow inundation at Mt. Etna

Scientific Reports, 2023
The development of probabilistic maps associated with lava flow inundation is essential to assess hazard in open vent volcanoes, especially those that have highly urbanized flanks.
Francesco Zuccarello, Giuseppe Bilotta, Gaetana Ganci, Cristina Proietti, Annalisa Cappello   +4 more
doaj   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Bit-Vector Model Counting using Statistical Estimation

, 2016
Approximate model counting for bit-vector SMT formulas (generalizing \#SAT) has many applications such as probabilistic inference and quantitative information-flow security, but it is computationally difficult.
A Cimatti, C Dwork, C Muise, Dmitry Chistikov, E Birnbaum, F Biondi, H Chen, J Burchard, JP Schmidt, L Kroc, L Moura de, Loi Luu, M Davis, M Soos, M Thurley, Mateus Borges, Miguel Castro, P Moral Del, Q Phan, S Chakraborty, V Ganesh, V Klebanov, Vladimir Klebanov, W Wei   +23 more
core   +1 more source

Fault Detection of Multi-Rate Two Phase Reactor Condenser System with Recycle Using Multiple Probabilistic Principal Component Analysis

Engineering Proceedings, 2023
Fault detection in multi-rate process systems is a challenging task. Common techniques used for fault detection include threshold-based detectors, statistical detectors, and machine learning-based detectors.
Dhrumil Gandhi, Meka Srinivasarao
doaj   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Modeling the Stock Market prior to large crashes

, 1998
We propose that the minimal requirements for a model of stock market price fluctuations should comprise time asymmetry, robustness with respect to connectivity between agents, ``bounded rationality'' and a probabilistic description.
Johansen, Anders, Sornette, Didier
core   +1 more source