Results 71 to 80 of about 514,307 (282)
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Stochastic semi-continuous simulation for extreme flood estimation in catchments with combined rainfall–snowmelt flood regimes [PDF]
Natural Hazards and Earth System Sciences, 2014 Simulation methods for extreme flood estimation represent an important complement to statistical flood frequency analysis because a spectrum of catchment conditions potentially leading to extreme flows can be assessed.
D. Lawrence +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies +3 more
wiley +1 more source
Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion
FEBS Open Bio, EarlyView.Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng +2 more
wiley +1 more source
Bernoulli Regression Models: Re-examining Statistical Models with Binary Dependent Variables [PDF]
The classical approach for specifying statistical models with binary dependent variables in econometrics using latent variables or threshold models can leave the model misspecified, resulting in biased and inconsistent estimates as well as erroneous ...
Bergtold, Jason S., Spanos, Aris
core +1 more source
Random environment on coloured trees
, 2007 In this paper, we study a regular rooted coloured tree with random labels assigned to its edges, where the distribution of the label assigned to an edge depends on the colours of its endpoints.
Menshikov, Mikhail +2 more
core +4 more sources
FEBS Open Bio, EarlyView.In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes +32 more
wiley +1 more source
Towards violation of Born's rule: description of a simple experiment
, 2010 Recently a new model with hidden variables of the wave type was elaborated, so called prequantum classical statistical field theory (PCSFT). Roughly speaking PCSFT is a classical signal theory applied to a special class of signals -- "quantum systems ...
Andrei Khrennikov +4 more
core +1 more source
Brodogradnja, 2017 This paper gives an approach to the probabilistic corrosion rate estimation model for inner bottom plates of bulk carriers. Firstly, by using the data from thickness measurements for inner bottom plates for considered 25 bulk carriers, the related best ...
Romeo Meštrović +2 more
doaj +1 more source