Results 91 to 100 of about 3,134,232 (365)

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Sensitivity of Bayesian Networks to Noise in Their Parameters

Entropy
There is a widely spread belief in the Bayesian network (BN) community that the overall accuracy of results of BN inference is not too sensitive to the precision of their parameters.
Agnieszka Onisko, Marek J. Druzdzel
doaj   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Seismic zonation of the Dead Sea Transform Fault area

Annals of Geophysics, 2000
The Dead Sea Transform Fault constitutes the northwestern boundary of the Arabian plate, accommodating the plate’s lateral movement relative to the African plate.
E. E. Papadimitriou, G. F. Karakaisis, K. Khair   +2 more
doaj   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Evaluating the Language Abilities of Large Language Models vs. Humans: Three Caveats

Biolinguistics
We identify and analyze three caveats that may arise when analyzing the linguistic abilities of Large Language Models. The problem of unlicensed generalizations refers to the danger of interpreting performance in one task as predictive of the models ...
Evelina Leivada, Vittoria Dentella, Fritz Günther   +2 more
doaj   +1 more source

Replication Regulates Volume Weighting in Quantum Cosmology

, 2009
Probabilities for observations in cosmology are conditioned both on the universe's quantum state and on local data specifying the observational situation.
Hartle, James, Hertog, Thomas
core   +3 more sources

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Saigo Space-Time Fractional Poisson Process via Adomian Decomposition Method

, 2017
We obtain the state probabilities of various fractional versions of the classical homogeneous Poisson process using an alternate and simpler method known as the Adomian decomposition method (ADM).
Kataria, K. K., Vellaisamy, P.
core   +1 more source

Predicted Probabilities' Relationship to Inclusion Probabilities

American Journal of Public Health, 2015
It has been shown that under a general multiplicative intercept model for risk, case-control (retrospective) data can be analyzed by maximum likelihood as if they had arisen prospectively, up to an unknown multiplicative constant, which depends on the relative sampling fraction.
Di, Fang, Jenny, Chong, Jeffrey R, Wilson   +2 more
openaire   +3 more sources