Results 61 to 70 of about 4,942,087 (308)
Molecular Oncology, EarlyView.There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes +20 more
wiley +1 more source
Improved Chebyshev inequality: new probability bounds with known supremum of PDF [PDF]
arXiv, 2018 In this paper, we derive new probability bounds for Chebyshev's inequality if the supremum of the probability density function is known. This result holds for one-dimensional or multivariate continuous probability distributions with finite mean and variance (covariance matrix).
arxiv
Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu +12 more
wiley +1 more source
Information-geometrical characterization of statistical models which are statistically equivalent to probability simplexes [PDF]
arXiv, 2017 The probability simplex is the set of all probability distributions on a finite set and is the most fundamental object in the finite probability theory. In this paper we give a characterization of statistical models on finite sets which are statistically equivalent to probability simplexes in terms of $\alpha$-families including exponential families ...
arxiv
Statistics-based adaptive non-uniform crossover for genetic algorithms [PDF]
, 2002 Copyright @ 2002 University of BirminghamThrough the population, genetic algorithm (GA) implicitly maintains the statistics about the search space. This implicit statistics can be used explicitly to enhance GA's performance.
Yang, S
core
Landscape of BRAF transcript variants in human cancer
Molecular Oncology, EarlyView.We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda +5 more
wiley +1 more source
Domain of attraction of Gaussian probability operators in quantum limit theory [PDF]
arXiv, 2009 We characterise the class of probability operators belonging to the domain of attraction of Gaussian limits in the setup which is a slight generalisation of Urbanik's scheme of noncommutative probability limit theorems.
arxiv
Molecular Oncology, EarlyView.In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton +17 more
wiley +1 more source
Mean and dispersion of harmonic measure [PDF]
arXiv, 2018 In this note, we provide and prove exact formulas for the mean and the trace of the covariance matrix of harmonic measure, regarded as a parametric probability distribution.
arxiv