Results 81 to 90 of about 1,688,548 (333)

Statistical tests for whether a given set of independent, identically distributed draws does not come from a specified probability density

open access: yes, 2010
We discuss several tests for whether a given set of independent and identically distributed (i.i.d.) draws does not come from a specified probability density function.
M. Tygert, STEPHENS
core   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

open access: yesFEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi   +6 more
wiley   +1 more source

Conventional Quantum Mechanics Without Wave Function and Density Matrix

open access: yes, 1999
The tomographic invertable map of the Wigner function onto the positive probability distribution function is studied. Alternatives to the Schr\"odinger evolution equation and to the energy level equation written for the positive probability distribution ...
Man'ko, Vladimir I.
core   +2 more sources

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

Encircling the dark: constraining dark energy via cosmic density in spheres

open access: yes, 2016
The recently published analytic probability density function for the mildly non-linear cosmic density field within spherical cells is used to build a simple but accurate maximum likelihood estimate for the redshift evolution of the variance of the ...
Bernardeau, F.   +4 more
core   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

A comparative analysis of parametric survival models and machine learning methods in breast cancer prognosis

open access: yesScientific Reports
Accurate prediction of breast cancer survival is critical for optimizing treatment strategies and improving clinical outcomes. This study evaluated a combination of parametric statistical models and machine learning algorithms to identify the most ...
Sonia Kaindal, B. Venkataramana
doaj   +1 more source

The Luminosity Function of Galaxies as modeled by a left truncated beta distribution

open access: yes, 2014
A first new luminosity functions of galaxies can be built starting from a left truncated beta probability density function, which is characterized by four parameters.
Zaninetti, L.
core   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

open access: yesFEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng   +2 more
wiley   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

open access: yesFEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru   +6 more
wiley   +1 more source

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