Results 81 to 90 of about 2,561,356 (330)

Encircling the dark: constraining dark energy via cosmic density in spheres

, 2016
The recently published analytic probability density function for the mildly non-linear cosmic density field within spherical cells is used to build a simple but accurate maximum likelihood estimate for the redshift evolution of the variance of the ...
Bernardeau, F., Codis, S., Pichon, C., Prunet, S., Uhlemann, C.   +4 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Statistics of cosmic density profiles from perturbation theory

, 2013
The joint probability distribution function (PDF) of the density within multiple concentric spherical cells is considered. It is shown how its cumulant generating function can be obtained at tree order in perturbation theory as the Legendre transform of ...
Bernardeau, Francis, Codis, Sandrine, Pichon, Christophe   +2 more
core   +2 more sources

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Mean velocity and suspended sediment concentration profile model of turbulent shear flow with probability density function

Earth Sciences Research Journal, 2017
This work purposes a general mean velocity and a suspended sediment concentration (SSC) model to express distribution at every point of the cross section of turbulent shear flow by using a probability density function method.
Guanglin Wu, Liangsheng Zhu, Fangcheng Li   +2 more
doaj   +1 more source

Improved Chebyshev inequality: new probability bounds with known supremum of PDF

, 2018
In this paper, we derive new probability bounds for Chebyshev's inequality if the supremum of the probability density function is known. This result holds for one-dimensional or multivariate continuous probability distributions with finite mean and ...
Nishiyama, Tomohiro
core   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Estimate the probability density function of maximum temperature for the Middle East

Przegląd Naukowy Inżynieria i Kształtowanie Środowiska, 2020
Pollution is one reasons for increase temperature which leads to increase the heat waves which have large socioeconomic and healthy impacts on Middle East.
Iqbal K. Al-Ataby, Amani I. Al-Tmimi
doaj   +1 more source

q-Moments remove the degeneracy associated with the inversion of the q-Fourier transform

, 2011
It was recently proven [Hilhorst, JSTAT, P10023 (2010)] that the q-generalization of the Fourier transform is not invertible in the full space of probability density functions for q > 1.
Curado, E. M. F., Jauregui, M., Tsallis, C.   +2 more
core   +3 more sources

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source