Results 41 to 50 of about 3,643,927 (240)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Analytical Description of the Diffusion in a Cellular Automaton with the Margolus Neighbourhood in Terms of the Two-Dimensional Markov Chain

Mathematics, 2023
The one-parameter two-dimensional cellular automaton with the Margolus neighbourhood is analyzed based on considering the projection of the stochastic movements of a single particle. Introducing the auxiliary random variable associated with the direction
Anton E. Kulagin, Alexander V. Shapovalov   +1 more
doaj   +1 more source

Multidimensional Stationary Probability Distribution for Interacting Active Particles

, 2015
We derive the stationary probability distribution for a non-equilibrium system composed by an arbitrary number of degrees of freedom that are subject to Gaussian colored noise and a conservative potential.
Di Leonardo, Roberto, Gnan, Nicoletta, Maggi, Claudio, Marconi, Umberto Marini Bettolo   +3 more
core   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Probability distribution of flood flows in Tunisia [PDF]

Hydrology and Earth System Sciences, 2008
L (Linear) moments are used in identifying regional flood frequency distributions for different zones Tunisia wide. 1134 site-years of annual maximum stream flow data from a total of 42 stations with an average record length of 27 years are considered ...
H. Abida, M. Ellouze
doaj  

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Distribution Features of Deviation and Determination of a Tolerance Method for Prefabricated Concrete Components

Buildings, 2023
According to the current standards for prefabricated buildings, the dimensional tolerances of components are usually determined by experience, lacking a theoretical basis. This work demonstrates the mathematical distribution of the dimensional deviations
Hao Long, Xiaoyong Luo, Jinhong Liu, Hongzhan Xiang   +3 more
doaj   +1 more source

Inversion of moments to retrieve joint probabilities in quantum sequential measurements

, 2013
A sequence of moments encode the corresponding probability distribution. Probing if quantum joint probability distribution can be retrieved from the associated set of moments -- realized in the sequential measurement of a dichotomic observable at ...
Devi, A. R. Usha, Karthik, H. S., Katiyar, Hemant, Mahesh, T. S., Rajagopal, A. K., Shukla, Abhishek   +5 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Using Mixed Probability Distribution Functions for Modelling Non-Zero Sub-Daily Rainfall in Australia

Geosciences, 2020
Probabilistic models for sub-daily rainfall predictions are important tools for understanding catchment hydrology and estimating essential rainfall inputs for agricultural and ecological studies.
Md Masud Hasan, Barry F. W. Croke, Shuangzhe Liu, Kunio Shimizu, Fazlul Karim   +4 more
doaj   +1 more source