Results 51 to 60 of about 6,388,345 (232)

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Filter Estimator Based on the Probability Distribution

IEEE Access
In this paper, we propose a model of a parameter estimator filter for Black Box-type Stochastic Systems (BBSS), that is, only its inputs and outputs are known; considering its intrinsic properties observed in the second probability moment, in which the ...
Romeo Urbieta Parrazalez, Rosaura Palma Orozco, Maria Teresa Zagaceta Alvarez, Jose Luis Fernandez Munoz, Karen Alicia Aguilar Cruz   +4 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Extended Rayleigh Probability Distribution to Higher Dimensions

Journal of Probability and Statistics
In this paper, we have derived and studied new probability distributions by extending the 2-dimensional Rayleigh distribution (RD). First, we extend the RD to 3 dimensions and then generalize it to k dimensions for any positive integer k ≥ 3.
Adugna Gelaw Yirsaw, Ayele Taye Goshu
doaj   +1 more source

Funções de distribuição diamétrica em um fragmento de Floresta Ombrófila Mista Diametric distribution functions in a fragment of Mixed Ombrophylous Forest

Ciência Rural, 2009
Os objetivos deste estudo foram ajustar e selecionar funções de densidade probabilística que caracterizem a estrutura diamétrica desse fragmento e das espécies: Cedrela fissilis (Cedro), Luehea divaricata (Açoita Cavalo), Gochnatia polymorpha (Cambará ...
Sebastião do Amaral Machado, Alan Lessa Derci Augustynczik, Rodrigo Geroni Mendes Nascimento, Saulo Jorge Téo, Eder Pereira Miguel, Marco Aurélio Figura, Luís César Rodrigues da Silva   +6 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

A New Index for Quantifying the Peakedness of a Probability Distribution

Mathematics
Peakedness is an important characteristic of probability distributions, and an effective method for quantifying peakedness is essential for statistical modeling and comparing different probability distributions in many practical applications.
Hening Huang
doaj   +1 more source

Delay-probability-distribution-dependent stability of uncertain stochastic genetic regulatory networks with time-varying delays

, 2013
This paper investigates the delay-probability-distribution-dependent stability problem of uncertain stochastic genetic regulatory networks (SGRNs) with time-varying delays.
S Lakshmanan (13601575), P Balasubramaniam (13640545), R Rakkiyappan (13601566)   +2 more
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