Results 71 to 80 of about 1,100,569 (292)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Filter Estimator Based on the Probability Distribution

IEEE Access
In this paper, we propose a model of a parameter estimator filter for Black Box-type Stochastic Systems (BBSS), that is, only its inputs and outputs are known; considering its intrinsic properties observed in the second probability moment, in which the ...
Romeo Urbieta Parrazalez, Rosaura Palma Orozco, Maria Teresa Zagaceta Alvarez, Jose Luis Fernandez Munoz, Karen Alicia Aguilar Cruz   +4 more
doaj   +1 more source

Funções de distribuição diamétrica em um fragmento de Floresta Ombrófila Mista Diametric distribution functions in a fragment of Mixed Ombrophylous Forest

Ciência Rural, 2009
Os objetivos deste estudo foram ajustar e selecionar funções de densidade probabilística que caracterizem a estrutura diamétrica desse fragmento e das espécies: Cedrela fissilis (Cedro), Luehea divaricata (Açoita Cavalo), Gochnatia polymorpha (Cambará ...
Sebastião do Amaral Machado, Alan Lessa Derci Augustynczik, Rodrigo Geroni Mendes Nascimento, Saulo Jorge Téo, Eder Pereira Miguel, Marco Aurélio Figura, Luís César Rodrigues da Silva   +6 more
doaj   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Modified Discrete PSO to Increase the Delivered Energy Probability in Distribution energy Systems

, 2013
This paper proposes a PSO based approach to increase the probability of delivering power to any load point by identifying new investments in distribution energy systems.
Vale, Zita, Bruno Canizes, Zita Vale, Morais, Hugo, Hugo Morais, Canizes, Bruno, Soares, João, Joao Soares   +7 more
core   +1 more source

Extended Rayleigh Probability Distribution to Higher Dimensions

Journal of Probability and Statistics
In this paper, we have derived and studied new probability distributions by extending the 2-dimensional Rayleigh distribution (RD). First, we extend the RD to 3 dimensions and then generalize it to k dimensions for any positive integer k ≥ 3.
Adugna Gelaw Yirsaw, Ayele Taye Goshu
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Shaping of molecular weight distribution using b-spline based predictive probability density function control

, 2004
Issues of modelling and control of molecular weight distributions (MWDs) of polymerization products have been studied under the recently developed framework of stochastic distribution control, where the purpose is to design the required control inputs ...
Zhang, J.F., null Liulin Cao, Yue, H., null Hong Yue, Wang, H., null Jinfang Zhang, Hong Wang, Cao, L.   +7 more
core   +1 more source

A New Index for Quantifying the Peakedness of a Probability Distribution

Mathematics
Peakedness is an important characteristic of probability distributions, and an effective method for quantifying peakedness is essential for statistical modeling and comparing different probability distributions in many practical applications.
Hening Huang
doaj   +1 more source

Prognostic Impact of European LeukemiaNet Genetic Risk Stratification System in Adult Patients With Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
This study aimed to evaluate the prognostic value of ELN2017 in predicting survival outcomes and to assess the impact of clinical and molecular factors such as age, FLT3 and NPM1 mutations, and allogeneic hematopoietic stem cell transplantation (allo‐HSCT).
Mobina Shrestha, Bishwas Mandal, Vishal Mandal, Asis Shrestha, Amir Babu Shrestha   +4 more
wiley   +1 more source