Results 41 to 50 of about 1,687,803 (280)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Probability density estimation using data projection

Lietuvos Matematikos Rinkinys, 2009
Nonparametric estimation of multivariate multimodal probability density is analysed. The projection pursuit density estimator was proposed by J.H. Friedman.
Mindaugas Kavaliauskas
doaj   +1 more source

Simulation-Based Evaluation of the Estimation Methods of Far-Red Solar-Induced Chlorophyll Fluorescence Escape Probability in Discontinuous Forest Canopies

Remote Sensing, 2020
The escape probability of Solar-induced chlorophyll fluorescence (SIF) can be remotely estimated using reflectance measurements based on spectral invariants theory.
Weiwei Liu, Shezhou Luo, Xiaoliang Lu, Jon Atherton, Jean-Philippe Gastellu-Etchegorry   +4 more
doaj   +1 more source

Maximum probability O-D matrix estimation in large-sized networks [PDF]

Iranian Journal of Numerical Analysis and Optimization, 2020
We propose a maximum probability model to estimate the origin-destination trip matrix in the networks, where the observed traffic counts of links and the target origin-destination trip demands are independent discrete random variables with known ...
M. Abareshi
doaj   +1 more source

Fuzzy ARTMAP, Slow Learning and Probability Estimation [PDF]

, 1993
A nonparametric probability estimation procedure using the fuzzy ARTMAP neural network is here described. Because the procedure does not make a priori assumptions about underlying probability distributions, it yields accurate estimates on a wide variety ...
Carpenter, Gail A., Grossberg, Stephen, Reynolds, John H.   +2 more
core   +1 more source

Estimation of protein folding probability from equilibrium simulations

, 2005
The assumption that similar structures have similar folding probabilities ($p_{fold}$) leads naturally to a procedure to evaluate $p_{fold}$ for every snapshot saved along an equilibrium folding-unfolding trajectory of a structured peptide or protein ...
Amedeo Caflisch, Enrico Guarnera, Francesco Rao, Giovanni Settanni, Hartigan J. A.   +4 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Probabilistic Modeling of Urban Vehicle Traffic Under COVID-19 Mobility Restrictions Using AI-Based Video Data: A Case Study in Cluj-Napoca

Vehicles
The COVID-19 pandemic and the resulting mobility restrictions significantly disrupted urban traffic patterns. This study quantitatively assesses the impact of these restrictions on vehicle flow at a signalized central intersection in Cluj-Napoca, Romania,
Nicolae Filip, Calin Iclodean, Marius Deac   +2 more
doaj   +1 more source

Estimating Probability of Gas Breakdown Using Grey-Fuzzy Logic

Advances in Electrical and Computer Engineering, 2013
Designing the protection system of high voltage power systems involves elucidating the properties of gas breakdown. This work presents a simplified mathematical approach based on grey and fuzzy methods to estimate the probability of gas breakdown ...
TSAI, M.-T., WEN, K.-L., WU, Y.-C., CHEN, M.-J.   +3 more
doaj   +1 more source