Results 181 to 190 of about 40,312 (249)

Multi-Target Tracking with Collaborative Roadside Units Under Foggy Conditions. [PDF]

Sensors (Basel)
Shi T, Wang X, Jiang W, Huang X, Cen M, Cao S, Zhou H.   +6 more
europepmc   +1 more source

AI Designed Conformation Locking Peptides Target STING to Restore Diabetic Wound Healing

Advanced Science, EarlyView.
A generative AI pipeline identifies SCP‐1, a conformation‐locking peptide that stabilizes inactive STING. Incorporated into a dual‐responsive hydrogel for localized, MMP‐9‐triggered release, SCP‐1 suppresses inflammation, promotes reparative macrophage polarization, and accelerates diabetic wound healing.
Xinyu Li, Haojie Fu, Zhe Wang, Xuanzhou Chen, Ruhong Zhang, Xudong Wang, Louis D. Zhang, Xiang Li, Datao Li   +8 more
wiley   +1 more source

Dorsal prefrontal cortex drives perseverative behavior in mice. [PDF]

Nat Commun
Lebedeva A, Wang Y, Funnell L, Terry B, Oh YJ, Miller K, Harris KD.   +6 more
europepmc   +1 more source

Tumor‐Derived Exosomal circAP2B1 Induces M2 Macrophage Polarization by Enhancing Mitochondrial Homeostasis to Promote Esophageal Squamous Cell Carcinoma Progression

Advanced Science, EarlyView.
ESCC‐derived exosomal circAP2B1 promotes tumor progression by reprogramming mitochondrial metabolism via the ESRRA/KPNA1/MFN2 axis to induce M2 polarization of macrophages. ABSTRACT Esophageal squamous cell carcinoma (ESCC) remodels the immunosuppressive tumor microenvironment via exosome‐mediated intercellular communication.
Yiru Wang, Gang Feng, Youyu Wang, Ruihao Liang, Haixia Pan, Kai Lei   +5 more
wiley   +1 more source

Multiscale reorganisation of colloidal aggregation by percolating bacterial networks.

Soft Matter
Stricker L, Charlton SGV, Secchi E.
europepmc   +1 more source

Crosstalk Between CTSB+ Glioblastoma Cells and S100A10+ Macrophages: A Self‐Reinforcing Circuit Promotes Immune Evasion and Limits Response to Immunotherapy

Advanced Science, EarlyView.
In glioblastoma, M2‐polarized macrophages secrete IL‐6, which activates STAT3 signaling in tumor cells to upregulate CTSB. Tumor‐derived CTSB binds the C‐terminus of macrophage S100A10, reinforcing M2 polarization and further IL‐6 secretion, thereby establishing a feedforward IL‐6/STAT3/CTSB/S100A10 loop. This cascade drives tumor growth, invasion, and
Hao Zhang, Nan Zhang, Xisong Liang, Jie Wen, Ziyu Dai, Wantao Wu, Shuyu Li, Songshan Feng, Zaoqu Liu, Zhiwei Xia, Peng Luo, Quan Cheng   +11 more
wiley   +1 more source

Holocene man-occupied caves and transformed wetlands as facilitating factors for Leishmania infantum in South America. [PDF]

Mem Inst Oswaldo Cruz
Ribeiro SP, Dias CP, Duarte RV, de Almeida MFB, Malta LGF, Andrade Filho JD, Reis AB, Pereira MH, Grelle CE, Valenzuela JG, Serafim TD, Gontijo NF.   +11 more
europepmc   +1 more source

CoSP: Reconfigurable Metamaterial Inverse Design via Contrastive Pretrained Large Language Model

Advanced Science, EarlyView.
In this work, CoSP (contrastive multi‐state pretrain), an intelligent inverse design method for reconfigurable metamaterials based on a contrastive pretrained large language model, is proposed. Numerical experiments demonstrate that CoSP can design reconfigurable metamaterial structures for multi‐state, multi‐band optical responses, showing great ...
Shujie Yang, Yuqi Zhang, Xuzhe Zhao, Yansong Tang, Kaichen Dong   +4 more
wiley   +1 more source

An unprecedented view of ocean currents from geostationary satellites. [PDF]

Nat Geosci
Lenain L, Srinivasan K, Barkan R, Pizzo N.   +3 more
europepmc   +1 more source

Photoelectric Imaging of the Optically Inactive Charge State of Silicon‐Vacancy Defects in Diamond

Advanced Science, EarlyView.
Although the doubly negative charge state of the SiV center in diamond is predicted to ionize only in the ultraviolet and is therefore considered optically inaccessible, we demonstrate visible‐range photoelectric imaging enabled by a previously unrecognized regime of laser‐assisted tunneling. ABSTRACT The investigation of optically active point defects
Ilia Chuprina, Gergő Thiering, Emilie Bourgeois, Anna Ermakova, Dmitry Budker, Adam Gali, Milos Nesladek, Petr Siyushev, Fedor Jelezko   +8 more
wiley   +1 more source