Results 21 to 30 of about 1,788,159 (256)
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Disaggregable Outage-Aware SNR Modeling Under PDL Uncertainty for Optical Network Digital Twins
IEEE Open Journal of the Communications SocietyPolarization-dependent loss (PDL) makes the post-equalization signal-to-noise ratio (SNR) of a coherent optical lightpath stochastic, with an outage-relevant lower tail that depends on the longitudinal interleaving of PDL elements and amplified ...
Enrico Miotto +4 more
doaj +1 more source
The Median Probability Model and Correlated Variables [PDF]
, 2021 The median probability model (MPM) (Barbieri and Berger, 2004) is defined as the model consisting of those variables whose marginal posterior probability of inclusion is at least 0.5. The MPM rule yields the best single model for prediction in orthogonal
Barbieri, Maria M. +7 more
core +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Narrowband Radio Technosignature Search Toward 3I/ATLAS with FAST
The Astrophysical Journal3I/ATLAS is the third confirmed interstellar object passing through the solar system. In this work, we conduct a narrowband radio technosignature search toward 3I/ATLAS using the Five-hundred-meter Aperture Spherical Telescope (FAST) L -band multibeam ...
Jian-Kang Li +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
On predictive probability matching priors
, 2008 Published in at http://dx.doi.org/10.1214/074921708000000048 the IMS Collections (http://www.imstat.org/publications/imscollections.htm) by the Institute of Mathematical Statistics (http://www.imstat.org)
openaire +3 more sources
The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection
Molecular Oncology, EarlyView.Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński +12 more
wiley +1 more source