Results 31 to 40 of about 2,906,323 (237)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

On Deneutrosophication [PDF]

Neutrosophic Sets and Systems, 2020
Deneutrosophication is a process to evaluate real output from neutrosophic information. The paper presents on a novel deneutrosophication algorithm. The process is developed with similarity measure and probability density function (PDF). This similarity
Kanika Mandal
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

A Limit Theorem for Twists of L-Functions of Elliptic Curves

Mathematical Modelling and Analysis, 2014
In the paper, a limit theorem for weakly convergent probability measures on the complex plane for twisted with Dirichlet character L-functions of elliptic curves with an increasing modulus of the character is proved.
Virginija Garbaliauskienė, Antanas Laurinčikas   +1 more
doaj   +1 more source

Packing dimensions of basins generated by distributions on a finite alphabet

Журнал Белорусского государственного университета: Математика, информатика, 2021
We consider a space of infinite signals composed of letters from a finite alphabet. Each signal generates a sequence of empirical measures on the alphabet and the limit set corresponding to this sequence.
Victor I. Bakhtin, Bruno Sadok
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

The Discrete Value Distribution of the Modified Mellin Transform of the Fourth Power of the Riemann Zeta-Function

Axioms
Let Z2(s) denote the modified Mellin transforms of the modulus of the fourth power of the Riemann zeta-function. This paper is devoted to the probabilistic properties of generalized discrete shifts Z2(s+iψ(k)), k∈N, with a certain differentiable function
Virginija Garbaliauskienė, Renata Macaitienė, Audronė Rimkevičienė, Mindaugas Stoncelis, Darius Šiaučiūnas   +4 more
doaj   +1 more source

On stationarity of Lagrangian observations of passive tracer velocity in a compressible environment

, 2004
We study the transport of a passive tracer particle in a steady strongly mixing flow with a nonzero mean velocity. We show that there exists a probability measure under which the particle Lagrangian velocity process is stationary.
Komorowski, Tomasz, Krupa, Grzegorz
core   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source