Advanced Science, EarlyView.MethyAnno enables robust and interpretable annotation of single‐cell DNA methylation data by integrating multi‐scale epigenetic information, bidirectional cross‐attention, and prototype‐based metric learning. The framework resolves rare and novel cell types across datasets while revealing cell‐type‐specific epigenetic signatures associated with disease
Yuhang Jia +4 more
wiley +1 more source
Calibrated, cost-sensitive, explainable ensemble learning for customer churn prediction in retail banking: a leakage-safe pipeline and single-dataset case study. [PDF]
Front Artif IntellKarim F +7 more
europepmc +1 more source
Single‐Cell Profiling Reveals Clonally Expanded CX3CR1+ T Cells in Anti‐NMDA Receptor Encephalitis
Advanced Science, EarlyView.CX3CR1+ T cells are associated with peripheral and central immune alterations in anti‐NMDA receptor encephalitis (NMDAR‐E). They show potential responsiveness to GluN1 (NR1) peptides, potential interactions with peripheral B cells, clonal expansion, increased CD137/CD154 expression, and inflammatory cytokine production. Their preferential cerebrospinal
Lin Yan +13 more
wiley +1 more source
Determinants of automobile loan default and prepayment [PDF]
The authors examine whether a borrower’s choice of automobile reveals information about future loan performance. They find that loans on most luxury automobiles have a higher probability of prepayment, while loans on most economy automobiles have a lower
Sumit Agarwal +2 more
core
Advanced Science, EarlyView.We use lysine‐to‐glutamine mutations to study the effect of electrostatics on the kinetics and thermodynamics of alpha‐synuclein amyloid fibril formation. We find that mutational effects map on their structural context within fibrils and identify residues that modulate the energy landscape of alpha‐synuclein self‐assembly. Our work outlines a scalable,
Antonin Kunka +10 more
wiley +1 more source
Performance of cardiovascular disease risk prediction tools in chronic obstructive pulmonary disease. [PDF]
Ann Am Thorac SocSalimian S +4 more
europepmc +1 more source
Estimation of the Default Risk of Publicly Traded Canadian Companies [PDF]
Two models of default risk are prominent in the financial literature: Merton's structural model and Altman's non-structural model. Merton's structural model has the benefit of being responsive, since the probabilities of default can continually be ...
Madalina Petrescu +3 more
core
Advanced Science, EarlyView.The WTP is a key component of static drainage PEMFCs, enabling cathode water removal and gas sealing through capillary forces. This work investigates the mechanisms governing WTP drainage and sealing performance and develops predictive approaches for WTP design optimization.
Mengdi Guo +3 more
wiley +1 more source
Tree-Based Machine Learning for Diagnostic Classification of Dengue Fever Using Routine Hematological Parameters: A Secondary Analysis of a Publicly Available Dataset. [PDF]
Diagnostics (Basel)Yilmaz ZB, Kucukakcali Z, Akbulut S.
europepmc +1 more source
The Determinants of Attitudes towards Strategic Default on Mortgages [PDF]
We use survey data to study American households' propensity to default when the value of their mortgage exceeds the value of their house even if they can afford to pay their mortgage (strategic default).
Luigi Guiso +2 more
core