Results 41 to 50 of about 423,933 (267)

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Reliability Assessment of Offshore Pipeline Due to Pitting Corrosion

International Journal of Maritime Technology, 2020
Pitting is one of the most localized forms of corrosion attacks which cannot be detected easily. Pitting decreases the pipe wall thickness and also the pipeline strength against environmental and operational loads.
Seyed Mohammad Hossein Sharifi, Nima Pirali   +1 more
doaj  

Analysis of viscoelastic behavior of a filled elastomer under action of different loads [PDF]

Hemijska Industrija, 2017
Mechanical properties of viscoelastic filled polymers strongly depend on temperature and strain rate and vary for several orders of magnitude. During service life, a viscoelastic body, especially carboxy-terminated polybutadiene (CTPB) composite solid ...
Gligorijević Nikola I., Živković Saša Ž., Kovačević Nenad V., Dimitrijević Nenad P., Pavković Bojan M., Pavić Miloš, Rodić Vesna Ž.   +6 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

A Probability-Based Framework for Evaluating Slope Failure Under Rainfall Using Coupled Finite Element Analysis

Geosciences
Rainfall is one of the major causes of geological hazards such as landslides and slope failures because it decreases shear strength along the failure surface and increases the driving force of the sliding mass due to the movement of the wetting front in ...
Nadarajah Ravichandran, Tharshikka Vickneswaran   +1 more
doaj   +1 more source

Structural Integrity of Fixed Offshore Platforms by Incorporating Wave-in-Deck

Journal of Marine Science and Engineering, 2021
The structural integrity of offshore platforms is affected by degradation issues such as subsidence. Subsidence involves large settlement areas, and it is one of the phenomena that may be experienced by offshore platforms throughout their lives ...
Nurul Uyun Azman, Mohd Khairi Abu Husain, Noor Irza Mohd Zaki, Ezanizam Mat Soom, Nurul Azizah Mukhlas, Sayyid Zainal Abidin Syed Ahmad   +5 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source