Results 51 to 60 of about 6,921,074 (265)

Simulation analysis of multi-objective one-dimensional cutting problems

Transactions on Computational Modeling and Intelligent Systems
In this paper, we compare published studies about optimization models for multi-objective one-dimensional cutting problems. Although all of the models address multiple objectives, they implement these goals in different ways.
Anett Rácz, Ákos Szabó
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Delay and Utilization Analysis of Roadside 5G NR IAB Deployments With Half-Duplex Constraints

IEEE Open Journal of the Communications Society
The standardized 3GPP integrated access and backhaul (IAB) technology is expected to provide a cost-efficient densification of 5G New Radio access networks. Relying on multi-hop communications, one of the critical metrics in such a system is latency.
Uliana Morozova, Egor Machnev, Vitalii Beschastnyi, Darya Ostrikova, Yuliya Gaidamaka, Yevgeni Koucheryavy, Konstantin Samouylov   +6 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Peak Age of Information Analysis in Systems with Multiple Time-Correlated Traffic Streams

Sensors
Nowadays, Internet of Things (IoT) is one of the most dynamically evolving services in the 5G ecosystem. In industrial IoT (IIoT), this service can be utilized to deliver state updates of various equipment to the remote control center for further ...
Varvara Manaeva, Elena Zhbankova, Ekaterina Markova, Konstantin Samouylov   +3 more
doaj   +1 more source

Convexity and robustness of the Rényi entropy

Modern Stochastics: Theory and Applications, 2021
We study convexity properties of the Rényi entropy as function of $\alpha >0$ on finite alphabets. We also describe robustness of the Rényi entropy on finite alphabets, and it turns out that the rate of respective convergence depends on initial alphabet.
Filipp Buryak, Yuliya Mishura
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Multiple perspectives on the concept of conditional probability [PDF]

, 2012
Conditional probability is a key to the subjectivist theory of probability; however, it plays a subsidiary role in the usual conception of probability where its counterpart, namely independence is of basic importance.
Borovcnik, Manfred
core