Results 61 to 70 of about 331,623 (300)

Probability for the Revision Theory of Truth [PDF]

Journal of Philosophical Logic, 2018
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Catrin Campbell-Moore, Leon Horsten, Hannes Leitgeb   +2 more
openaire   +3 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Probability Theory on Fuzzy Sets

, 2017
Similarly as the Kolmogorov probability theory in the first half of the 20th century, the Zadeh fuzzy set theory played a significant role in the second half of the 20th century.
Beloslav Riečan, Renáta Bartková, Anna Tirpáková   +2 more
core   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Queueing Systems with Unstable Service Units as Mathematical Models of Hybrid Energy Systems

Mathematics
The growing number of electronic devices and the development of distributed computing systems make the problem of energy shortages relevant. At the same time, there is a global trend towards a transition to renewable energy, which, although it ...
Ekaterina Fedorova, Yana Tyulenina, Valery Churakov   +2 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Basic Probability Theory

, 2021
Long title: Basic Probability Theory: Independent Random Variables and Sample Spaces. Chapters: Elementary Probability - Basic Probability - Canonical Sample Spaces - Working on Probability Spaces - A Solutions to ...
Menaldi, Jose Luis
core   +1 more source

Performance of the Novel Reactive Access-Barring Scheme for NB-IoT Systems Based on the Machine Learning Inference

Sensors
Modern 5G+grade low power wide area network (LPWAN) technologies such as Narrowband Internet-of-Things (NB-IoT) operate utilizing a multi-channel slotted ALOHA algorithm at the random access phase.
Anastasia Daraseliya, Eduard Sopin, Julia Kolcheva, Vyacheslav Begishev, Konstantin Samouylov   +4 more
doaj   +1 more source

Belief and probability: A general theory of probability cores

International Journal of Approximate Reasoning, 2012
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Horacio L. Arló-Costa, Arthur Paul Pedersen   +1 more
openaire   +1 more source