Results 111 to 120 of about 1,248,041 (248)

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

IJMPR Didactic Paper: Weighting for Causal Inference in Mental Health Research

International Journal of Methods in Psychiatric Research
Objective Inverse probability weighting is a fundamental and general methodology for estimating the causal effects of exposures and interventions, but standard approaches to constructing such weights are often suboptimal.
Eric R. Cohn, José R. Zubizarreta
doaj   +1 more source

Is brain activity observable that leads to an evaluation of a probability of 0.5 that is different from 0.5 in binary lottery choices? [PDF]

This paper focuses on the problem of probability weighing in the evaluation of lotteries. According to Prospect Theory a probability of 0.5 has a weight of smaller than 0.5.
Bodo Vogt, Marcus Heldmann, Ralf Morgenstern, Thomas Münte   +3 more
core  

Thalamo‐Lesional Connectivity Signatures of Bilateral Tonic–Clonic Seizures in Focal Cortical Dysplasia‐Related Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Focal cortical dysplasia (FCD) is the most common etiology of drug‐resistant epilepsy in children. Focal to bilateral tonic–clonic seizures (FBTCS) mark a high risk of drug‐resistant epilepsy and involve thalamocortical circuitry in their generation and propagation.
Hua Xie, Xiaotong Li, Venkata Sita Priyanka Illapani, Leigh N. Sepeta, Jason Schroeder, Chima O. Oluigbo, Madison M. Berl, William D. Gaillard, Nathan T. Cohen   +8 more
wiley   +1 more source

Rituximab in Myasthenia Gravis: a real-world study using inverse probability of treatment weighting

Frontiers in Neurology
BackgroundThe role of rituximab in the treatment of myasthenia gravis (MG) remains uncertain due to limited randomized controlled evidence and heterogeneous observational data. While rituximab is often used in refractory MG, its comparative effectiveness
Yong Lin Wang, Yong Lin Wang, Chao Zhu, Mahima Kapoor, Mahima Kapoor, Gary Cutter, Carolina Barnett-Tapia, Helmut Butzkueven, Helmut Butzkueven, Wenwen Zhang, Gabor Lovas, Csilla Rozsa, Jeannine Heckmann, Stefan Blum, Laurie McLaughlin, Katherine Buzzard, Katherine Buzzard, Yi Chao Foong, Yi Chao Foong, Elisabeth Chroni, Dimitra Veltsista, Belinda Cruse, Belinda Cruse, Mina Botrous, Mina Botrous, Stephen Reddel, Mastura Monif, Mastura Monif, Anneke van der Walt, Anneke van der Walt   +29 more
doaj   +1 more source

The shape of the utility function under risk in the loss domain and the "ruinous losses" hypothesis: some experimental results [PDF]

This paper reports some preliminary experimental results as regards the shape of the utility function for losses when elicited over a wide interval of consequences.
Nathalie Etchart-Vincent
core  

Clinical and Modifiable Factors Associated With Disability and Relapse in MOGAD: A Multicentre Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Factors associated with relapse course and disability in myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD) remain incompletely understood. Objectives To identify clinical and modifiable factors associated with relapse and disability in MOGAD. Methods In this ambispective multicentre cohort study using data from
Yingtao Wang, Shaoxin Tao, Qiujia Wang, Xiaoyu Xu, Hui Yao, Zheng Liu, Dawei Li, Zhandong Qiu, Jinming Han, Jiangwei Xia, Qi Wang, Jun Sun, Kai Shao, Jiao Li, Shishuang Ruan, Yi Zhong, Jun Guo, Shougang Guo, Yue Huang, Guoliang Chai, Tao Jin, Hongyu Zhou, Junwei Hao, Yinan Zhao   +23 more
wiley   +1 more source

Efficacy and Safety of Antiplatelet Therapy After Endovascular Aortic Repair: A Target Trial Emulation

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The optimal antiplatelet regimen after standard endovascular aneurysm repair (EVAR) in patients without atherosclerotic cardiovascular disease remains uncertain.
Ki Hong Choi, Danbee Kang, Jihee Nam, Take Kyu Park, Myung Gyu Song, Tae‐Seok Seo, Woo Jin Yang, Seung‐Hyuk Choi   +7 more
doaj   +1 more source

Factors Associated With the Rising Trend in Self‐Reported Cognitive Disability Among U.S. Adults Aged 18–39 From 2013–2024

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Building on our prior Behavioral Risk Factor Surveillance System analysis identifying adults aged 18–39 as the primary driver of the national increase in self‐reported cognitive disability, we examined factors associated with this rise using 2013–2024 U.S. BRFSS data. Methods We analyzed U.S.
Adam de Havenon, Ka‐Ho Wong, Mirriam Mananah, Christopher D. Anderson, Ada Fenick, Amy Arnsten, Arman Fesharaki‐Zadeh, James C. McPartland, Mary L. Adams, Kevin N. Sheth   +9 more
wiley   +1 more source

Effect of Fluoroscopy‐Only Versus Transesophageal Echocardiography/Intracardiac Echocardiography Guidance in Left Atrial Appendage Occlusion on Stroke Prevention: Analysis From the RECORD I Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Evidence regarding the link between imaging modality and stroke prevention outcomes of left atrial appendage occlusion is currently lacking.
Ping Wang, Zhengquan Chen, Yongmeng Yan, Guotao Fu, Jianzheng Liu, Ruining Zhang, Zhongbao Ruan, Xianxian Zhao, Haixiong Wang, Baopeng Tang, Xuegang Xie, Fu Yi, Yuan Bai, Xianhui Zhou, Junguo Zhu, Hongde Hu, Scot Garg, Patrick W. Serruys, Chao Gao, Ling Tao   +19 more
doaj   +1 more source