Results 51 to 60 of about 5,841 (245)

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Penerapan Model Pembelajaran Probing-Prompting untuk Meningkatkan Kemampuan Koneksi Matematis [PDF]

GAUSS: Jurnal Pendidikan Matematika, 2019
Penelitian ini bertujuan utuk mengetahui dan mendapatkan data aktual tentang penerapan model pembelajaran probing-prompting untuk meningkatkan kemampuan koneksi matematika siswa. Penelitian ini dilakukan di SMA Negeri 3 Pandeglang tahun ajaran 2018/2019. Metode yang digunakan adalah metode kuasi eksperimen.
Sartika, Nenden Suciyati, Yulita, Susti Rahmah   +1 more
openaire   +2 more sources

Improving Students’ Speaking Skill Through Probing-Prompting Method at SMA Advent Makassar

EDUKASI, 2023
This research is intended to find out the significant difference of the speaking skill of the second year students at SMA Advent Makassar through Probing-Prompting method. The method of this research is pre- experimental method. This method involved one group that was given pre- test, treatments and post-test.The result of the data analysis shows that ...
Yultri Silamma, Demsi Ronald Claus Matiallo, Suardi Suardi   +2 more
openaire   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Probing Prompt Design for Socially Compliant Robot Navigation with Vision Language Models

CoRR
Language models are increasingly used for social robot navigation, yet existing benchmarks largely overlook principled prompt design for socially compliant behavior. This limitation is particularly relevant in practice, as many systems rely on small vision language models (VLMs) for efficiency.
Ling Xiao 0001, Toshihiko Yamasaki
openaire   +2 more sources

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Effectiveness of Probing-prompting Learning Models with Scaffolding Strategy to Mathematic Creative Thinking Ability and Enthusiasm

Unnes Journal of Mathematics Education, 2017
The purpose of this research was to know that the learning model ProbingPrompting with Scaffolding strategy effective on the mathematic creative thinking ability and enthusiasm.
Miftah Hafidz Alfian, Dwijanto Dwijanto, Sunarmi Sunarmi   +2 more
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source