Results 71 to 80 of about 229,681 (276)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Effectiveness of Probing-prompting Learning Models with Scaffolding Strategy to Mathematic Creative Thinking Ability and Enthusiasm

Unnes Journal of Mathematics Education, 2017
The purpose of this research was to know that the learning model ProbingPrompting with Scaffolding strategy effective on the mathematic creative thinking ability and enthusiasm.
Miftah Hafidz Alfian, Dwijanto Dwijanto, Sunarmi Sunarmi   +2 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Prompting Candidates in Oral Assessment Contexts: A Taxonomy and Guiding Principles

Journal of Medical Education and Curricular Development, 2020
Prompting is an aspect of oral assessment that deserves more attention. There appears to be considerable variation in how practitioners conceptualise prompting and how it is deployed in practice.
Jacob Pearce, Neville Chiavaroli
doaj   +1 more source

PENERAPAN MODEL DISCOVERY LEARNING DENGAN TEKNIK PROBING PROMPTING TERHADAP KEMAMPUAN KOGNITIF PESERTA DIDIK [PDF]

, 2019
Penelitian ini adalah untuk mengetahui (1) hasil kemampuan kognitif sebelum diterapkan model discovery learning dengan teknik probing prompting dalam pembelajaran fisika, (2) hasil kemampuan kognitif setelah diterapkan model discovery learning dengan ...
Al-Hadid, Syarifa Alam, Humairah, Nur Aisyah, Sartika, Dewi   +2 more
core   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Automated Attribution Graph Interpretation via Probe Prompting

Even though we know the precise computations that lead from a large language model (LLM) input to its output this computation remains very hard to interpret. One way to make it easier to understand this process is by creating a sparse computational graph that captures most of the model behavior with smallest number of computational nodes.
Birardi, Giuseppe, Paulo, Gonçalo
openaire   +2 more sources

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

PENGARUH MODEL PEMBELAJARAN PROBING-PROMPTING TERHADAP HASIL BELAJAR MATEMATIKA MI PODOREJO SUMBERGEMPOL KAB.TULUNGAGUNG [PDF]

, 2020
ABSTRAK Skripsi dengan judul “Pengaruh Model Pembelajaran Probing-Prompting terhadap Hasil Belajar Matematika MI Podorejo Sumbergempol Kabupaten Tulungagung” ini ditulis oleh Rifka Ameiliyanti, NIM.17205163282, Fakultas Tarbiyah Ilmu Keguruan ...
RIFKA AMEILIYANTI, 17205163282
core   +1 more source