Results 91 to 100 of about 138,712 (307)

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Intestinal Dysbiosis and the Developing Lung: The Role of Toll-Like Receptor 4 in the Gut-Lung Axis. [PDF]

, 2020
BackgroundIn extremely premature infants, postnatal growth restriction (PNGR) is common and increases the risk of developing bronchopulmonary dysplasia (BPD) and pulmonary hypertension (PH). Mechanisms by which poor nutrition impacts lung development are
Chiamvimonvat, Nipavan, Gerard, Kimberly, Halloran, Katrina, Hanhauser, Ashley, Lakshminrusimha, Satyan, Monacelli, Sveva, Steinhorn, Robin H, Thai, Phung N, Underwood, Mark A, Warford, Cris, Wedgwood, Stephen   +10 more
core  

Oral Bioinspired Peroxisome‐Engineered Probiotics for Modulating Gut Microbiota Homeostasis and Alleviating Cardiac Chemotherapy Toxicity

Advanced Science, EarlyView.
This study developed an oral bioinspired peroxisome‐engineered probiotic (BPEP) by anchoring lipid‐encapsulated ruthenium nanozymes onto Escherichia coli Nissle 1917, utilizing probiotics to deliver nanozymes to the intestinal barrier for reactive oxygen species/reactive nitrogen species elimination, tight junction restoration, and gut microbiota ...
Shuyu Wang, Xiaowan Fan, Chao Zhang, Shuai Han, Yike Guo, Yuchen Wang, Wei Wang, Junyue Xing, Ying Liu, Wei Jiang, Xiaoying Chen   +10 more
wiley   +1 more source

In Vitro Fermentation Characteristics and Rumen Microbial Population of Diet Supplemented with Saccharomyces Cerevisiae and Rumen Microbe Probiotics [PDF]

, 2016
The objective of this study was to select three strains of probiotic Saccharomyces cerevisiae and to evaluate the effect of S. cerevisiae and rumen bacteria isolate (MR4) supplementation and their combination on rumen fermentability and rumen microbial ...
Evvyernie, D. (Dwierra), Riyanti, L. (Lilis), Suryahadi, S. (Suryahadi)   +2 more
core  

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source

Incorporating a mucosal environment in a dynamic gut model results in a more representative colonization by lactobacilli [PDF]

, 2011
To avoid detrimental interactions with intestinal microbes, the human epithelium is covered with a protective mucus layer that traps host defence molecules. Microbial properties such as adhesion to mucus further result in a unique mucosal microbiota with
Derde, Melanie, Eeckhaut, Venessa, MacKenzie, Donald A, Marzorati, Massimo, Possemiers, Sam, Roos, Stefaan, Van de Wiele, Tom, Van den Abbeele, Pieter, Van Immerseel, Filip, Vanhoecke, Barbara, Verstraete, Willy   +10 more
core   +2 more sources

A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity

Advanced Science, EarlyView.
This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu, Xinyu Sun, Wanxia Ma, Jianming Yang, Xuan Sun, Lisong Zhang, Yumeng Liu, Tianshu Ren, Qi Wang, Jingyu Wang, Xiao Li, Xianping Peng, Liu Yang, Junqiang Lv, Zhi Yao, Zhi‐Song Zhang, Quan Wang   +16 more
wiley   +1 more source

Effect of probiotic inocula on the population density of lactic acid bacteria and enteric pathogens in the intestine of weaning piglets [PDF]

, 2007
Because antibiotic resistance occurs in bacteria at an alarming rate, significant research has been focused on finding alternative treatments which do not involve the use of antibiotics.
Biavati, Bruno, Bosi, Paolo, D'Aimmo, Maria Rosaria, Mazzoni, Maurizio, Modesto, Monica, Stefanini, Ilaria, Tittarelli, Carla, Trevisi, Paolo   +7 more
core  

Identifying Cytokine Motif‐Containing, Immunomodulatory Bacterial Proteins in Human Gut Microbiome

Advanced Science, EarlyView.
By building and constructing HMM (Upper left, blue), the authors identify CMCPs in bacteria genomes and CRC related metagenomes and enriched CRC‐related CMCPs (Upper right, blue). They analyze sequence and structural similarity of hits (Lower left, green), test function with engineered EcN delivered to tumors in a mouse tumor model (Lower right, pink ...
Ziyu Wang, Siqi Guo, Jing Li, Qianqian Huang, Jing Ning, Binbin Xia, Xun Lv, Xiang Liu, Zeyu Gao, Jine Li, Longchao Liu, Moshi Song, Jun Wang   +12 more
wiley   +1 more source

Functional Profiling of Enterococcus and Pediococcus Strains: An In Vitro Study on Probiotic and Postbiotic Properties

Microorganisms
The rising threat of antimicrobial resistance (AMR) has driven the search for safe and effective alternatives to conventional antibiotics. This study investigated the probiotic potential and postbiotic properties of Enterococcus faecium (one strain ...
Mircea-Cosmin Pristavu, Filofteia Camelia Diguță, Alexandru Constantin Aldea, Florentina Badea, Mihaela Dragoi Cudalbeanu, Alina Ortan, Florentina Matei   +6 more
doaj   +1 more source