Results 61 to 70 of about 1,027,084 (263)
The problem of identity in patristic understanding
Консультативная психология и психотерапия, 2011 Author examines approaches to self-consciousness and identity as parts of moral consciousness, based on the writings of the Fathers of the Church, as well as representatives of the Russian theological schools.
Archbishop Ignatius
doaj
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
The problem of scene understanding by artificial autonomous agents
Zagadnienia Filozoficzne w NauceIn this paper, the problem of scene understanding in the context of autonomous robotics is considered. The implemented solutions, based on various types of artificial intelligence systems, are described and the perspectives of their development are ...
Andrzej Bielecki, Marzena Bielecka
doaj +1 more source
Understanding 'The Problem of Social Cost' [PDF]
SSRN Electronic Journal, 2013 This paper examines the positions of Coase and Pigou in regard to the problem of external effects (externalities). Assessing their two most important works, it appears that Coase has a more relevant preference for an evaluation of total efficiency, while Pigou, with some exceptions, is convinced that it is almost always socially desirable to reach ...
openaire +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Corrigendum: Editorial: Visual Snow: Old Problem, New Understanding. [PDF]
Front Neurol, 2022 White OB +3 more
europepmc +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Editorial: Visual Snow: Old Problem, New Understanding. [PDF]
Front Neurol, 2022 White OB +3 more
europepmc +1 more source
Understanding Dubious Future Problems [PDF]
, 2008 Peer ...
Oguz Mülâyim, Josep Lluís Arcos
openaire +2 more sources
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source